临床合理用药杂志
臨床閤理用藥雜誌
림상합리용약잡지
Chinese Journal of Clinical Rational Drug Use
2015年
32期
1-2
,共2页
多层螺旋 CT%同型半胱氨酸%冠心病
多層螺鏇 CT%同型半胱氨痠%冠心病
다층라선 CT%동형반광안산%관심병
Multislice spiral computed tomography%Homocysteine%Coronary heart disease
目的：通过对冠心病患者行64排螺旋 CT 检查和同型半胱氨酸（Hcy）水平检测，探讨其对冠状动脉斑块稳定性的预测价值。方法选择拟诊为冠心病的患者83例为研究对象，所有患者均行冠状动脉 CT 和冠状动脉造影检查，冠状动脉 CT 未见粥样硬化者纳入对照组，其余患者根据冠状动脉造影结果及病史分为急性冠状动脉综合症组，稳定型心绞痛组，再根据冠状动脉 CT 检查结果，分为易损斑块组，混合斑块组、稳定斑块组，所有患者均行血清Hcy 检测。结果易损斑块在 ACS 组的分布高于 SAP 组（P ﹤0.05），稳定斑块在 SAP 组的分布高于 ACS 组（P ﹤0.05）。ACS 组和 SAP 组 Hcy 水平均高于对照组（ P ﹤0.05），ACS 组 Hcy 水平高于 SAP 组（P ﹤0.05）。易损斑块组、混合斑块组、稳定斑块组 Hcy 水平均高于对照组（P ﹤0.05），且易损斑块组 Hcy 水平﹥混合斑块组﹥稳定斑块组，差异均有统计学意义（P ﹤0.05）。结论 Hcy 结合冠状动脉 CT 对冠状动脉斑块的不稳定性有预测价值。
目的：通過對冠心病患者行64排螺鏇 CT 檢查和同型半胱氨痠（Hcy）水平檢測，探討其對冠狀動脈斑塊穩定性的預測價值。方法選擇擬診為冠心病的患者83例為研究對象，所有患者均行冠狀動脈 CT 和冠狀動脈造影檢查，冠狀動脈 CT 未見粥樣硬化者納入對照組，其餘患者根據冠狀動脈造影結果及病史分為急性冠狀動脈綜閤癥組，穩定型心絞痛組，再根據冠狀動脈 CT 檢查結果，分為易損斑塊組，混閤斑塊組、穩定斑塊組，所有患者均行血清Hcy 檢測。結果易損斑塊在 ACS 組的分佈高于 SAP 組（P ﹤0.05），穩定斑塊在 SAP 組的分佈高于 ACS 組（P ﹤0.05）。ACS 組和 SAP 組 Hcy 水平均高于對照組（ P ﹤0.05），ACS 組 Hcy 水平高于 SAP 組（P ﹤0.05）。易損斑塊組、混閤斑塊組、穩定斑塊組 Hcy 水平均高于對照組（P ﹤0.05），且易損斑塊組 Hcy 水平﹥混閤斑塊組﹥穩定斑塊組，差異均有統計學意義（P ﹤0.05）。結論 Hcy 結閤冠狀動脈 CT 對冠狀動脈斑塊的不穩定性有預測價值。
목적：통과대관심병환자행64배라선 CT 검사화동형반광안산（Hcy）수평검측，탐토기대관상동맥반괴은정성적예측개치。방법선택의진위관심병적환자83례위연구대상，소유환자균행관상동맥 CT 화관상동맥조영검사，관상동맥 CT 미견죽양경화자납입대조조，기여환자근거관상동맥조영결과급병사분위급성관상동맥종합증조，은정형심교통조，재근거관상동맥 CT 검사결과，분위역손반괴조，혼합반괴조、은정반괴조，소유환자균행혈청Hcy 검측。결과역손반괴재 ACS 조적분포고우 SAP 조（P ﹤0.05），은정반괴재 SAP 조적분포고우 ACS 조（P ﹤0.05）。ACS 조화 SAP 조 Hcy 수평균고우대조조（ P ﹤0.05），ACS 조 Hcy 수평고우 SAP 조（P ﹤0.05）。역손반괴조、혼합반괴조、은정반괴조 Hcy 수평균고우대조조（P ﹤0.05），차역손반괴조 Hcy 수평﹥혼합반괴조﹥은정반괴조，차이균유통계학의의（P ﹤0.05）。결론 Hcy 결합관상동맥 CT 대관상동맥반괴적불은정성유예측개치。
Objective Doubtful or diagnosed coronary heart disease patients were conducted with 64-multislice spiral computed tomography,at the same time,homocysteine(Hcy)were determined. To investigate the value of 64-MSCT combined with Hcy for estimating the stability of coronary artery plaques of patients with coronary heart disease. Methods 83 in-hospital doubtful or diagnosed coronary heart disease patients admitted to our hospital were enrolled. All patients conducted with CT tomography and coronary angiography( CAG),the result of CT tomography of who were negative,were divided into control group,According to the results of CAG and medical history,the others were divided into acute coronary syndrome( ACS) group,stable angina pectoris(SAP)group. According to the results of coronary artery plaques detected by MSCT,both ACS and SAP groups were further divided into vulnerable plaque group,mixed plaque group and stable plaque group. The levels of serum homocysteine(Hcy)were measured. Results The distribution of vulnerable plaques in ACS group was higher than that in SAP group(P ﹤ 0. 05),while that of stable plaques lower than in SAP group(P ﹤ 0. 05). The levels of homocysteine in SAP and ACS group were higher than those in control group(P ﹤ 0. 05),and there was significant difference betwween SAP and ACS groups(P ﹤ 0. 05). The levels of homocysteine in every plaque group were all obviously higher than those in the control group(P ﹤ 0. 05),and those in vulnerable and mixed plaque group were also higher than those in stable plaque group(P ﹤0. 05). The levels of homocysteine in vulnerable plaque group were higher than those in mixed plaque group(P ﹤0. 05). Conclu-sion The detection of 64-MSCT combined with homocysteine(Hcy)had predictive value of unstable coronary artery plaques.
