中西医结合研究
中西醫結閤研究
중서의결합연구
Research of Integrated Traditional Chinese and Western Medicine
2015年
5期
225-227
,共3页
子宫颈癌患者%肾阳虚%右归饮%免疫功能
子宮頸癌患者%腎暘虛%右歸飲%免疫功能
자궁경암환자%신양허%우귀음%면역공능
cervical cancer patients%kidney Yang deficiency%Yougui Yin%immune function
目的：探讨右归饮对肾阳虚型子宫颈癌患者术后 CD8+ CD28- T 细胞免疫功能的影响。方法搜集72例肾阳虚型子宫颈癌术后患者，将患者随机分为观察组和对照组，并选择33例健康者作为健康对照组。观察组35例给予右归饮治疗，对照组37例给予常规治疗，比较治疗前及治疗3个月后2组患者 CD8+ CD28- T 细胞及其细胞因子白介素10(IL-10)及转化生长因子β1(TGF-β1)百分含量变化。结果治疗前，观察组与对照组的 CD8+ CD28- T 细胞、IL-10及 TGF-β1差异无统计学意义，且均显著高于健康对照组(P <0.05)。治疗后，观察组 CD8+ CD28- T 细胞、IL-10及 TGF-β1水平均较治疗前明显下降(P <0.05)，且均显著低于对照组(P <0.05)。结论 CD8+ CD28- T 细胞及其细胞因子升高是子宫颈癌患者的重要表现，右归饮可显著下调肾阳虚型子宫颈癌患者术后 CD8+ CD28- T 细胞的免疫功能。
目的：探討右歸飲對腎暘虛型子宮頸癌患者術後 CD8+ CD28- T 細胞免疫功能的影響。方法搜集72例腎暘虛型子宮頸癌術後患者，將患者隨機分為觀察組和對照組，併選擇33例健康者作為健康對照組。觀察組35例給予右歸飲治療，對照組37例給予常規治療，比較治療前及治療3箇月後2組患者 CD8+ CD28- T 細胞及其細胞因子白介素10(IL-10)及轉化生長因子β1(TGF-β1)百分含量變化。結果治療前，觀察組與對照組的 CD8+ CD28- T 細胞、IL-10及 TGF-β1差異無統計學意義，且均顯著高于健康對照組(P <0.05)。治療後，觀察組 CD8+ CD28- T 細胞、IL-10及 TGF-β1水平均較治療前明顯下降(P <0.05)，且均顯著低于對照組(P <0.05)。結論 CD8+ CD28- T 細胞及其細胞因子升高是子宮頸癌患者的重要錶現，右歸飲可顯著下調腎暘虛型子宮頸癌患者術後 CD8+ CD28- T 細胞的免疫功能。
목적：탐토우귀음대신양허형자궁경암환자술후 CD8+ CD28- T 세포면역공능적영향。방법수집72례신양허형자궁경암술후환자，장환자수궤분위관찰조화대조조，병선택33례건강자작위건강대조조。관찰조35례급여우귀음치료，대조조37례급여상규치료，비교치료전급치료3개월후2조환자 CD8+ CD28- T 세포급기세포인자백개소10(IL-10)급전화생장인자β1(TGF-β1)백분함량변화。결과치료전，관찰조여대조조적 CD8+ CD28- T 세포、IL-10급 TGF-β1차이무통계학의의，차균현저고우건강대조조(P <0.05)。치료후，관찰조 CD8+ CD28- T 세포、IL-10급 TGF-β1수평균교치료전명현하강(P <0.05)，차균현저저우대조조(P <0.05)。결론 CD8+ CD28- T 세포급기세포인자승고시자궁경암환자적중요표현，우귀음가현저하조신양허형자궁경암환자술후 CD8+ CD28- T 세포적면역공능。
Objective To study the effect of Yougui Yin on the CD8 + CD28 - T cells’function for the cervical cancer patients of kidney yang deficiency who underwent excision.Methods Seventytwo cases of postoperative cervical cancer patients with kidney Yang deficiency were included.Thirtyfive cases in the observation group were given Yougui Yin;the other 37 cases in the control group were not given Yougui Yin.CD8 + CD28 - T cells,interleu-kin 10(IL-10),and transforming growth factor beta 1 (TGF-β1 )were compared before and after treatment in the two groups.Results Before treatment,there were no statistical differences for CD8 + CD28 - T cells,IL-10 and TGF-β1 between the observation group and the control group,and all of these were significantly higher than those of healthy people(P <0.05).After treatment,CD8 + CD28 - T cells,IL-10 and TGF-β1 in the observation group was significantly reduced(P <0.05),and were significantly lower than those of the control group(P <0.05).Conclusion The increase of CD8 + CD28 - T cells and its cytokines is one of the important manifestations in cervical cancer pa-tients with kidney Yang deficiency;Yougui Yin can significantly improve by down-regulating CD8 + CD28 - T cell immune function.
