CAJ | 학술논문

慢性乙型肝炎是由乙型肝炎病毒（hepatitis B virus ，HBV ）引起的全球性传染病，HBV感染是我国肝硬化、原发性肝癌的重要原因。目前，干扰素类与核苷（酸）类似物抗病毒药物已广泛应用于临床，在一定程度上抑制了病毒的复制并控制了疾病的发展，但仍未从根本上清除病毒；各种治疗性疫苗在抗HBV方面也取得了一定疗效，但临床效果不佳。目前不少研究结果表明，生物免疫治疗可以成功清除体内的 HBV ，从而为乙肝的治疗带来新的希望。
만성을형간염시유을형간염병독（hepatitis B virus ，HBV ）인기적전구성전염병，HBV감염시아국간경화、원발성간암적중요원인。목전，간우소류여핵감（산）유사물항병독약물이엄범응용우림상，재일정정도상억제료병독적복제병공제료질병적발전，단잉미종근본상청제병독；각충치료성역묘재항HBV방면야취득료일정료효，단림상효과불가。목전불소연구결과표명，생물면역치료가이성공청제체내적 HBV ，종이위을간적치료대래신적희망。
Chronic hepatitis B is a worldwide infectious diseases caused by hepatitis B virus (HBV) .HBV infection is an important reason for liver cirrhosis and liver cancer in our country .Currently ,the interferon and nucleoside analogs antiviral drugs (nucleotides) is widely used in clinical practice .These drugs inhibit the replication of the virus and disease development to a certain extent ,but not fundamentally eliminate the virus .Various therapeutic vaccines have also made certain curative effect in anti HBV ,but the effect is not perfect clinically .At present ,many research results demonstrate that biological immu-notherapy can successfully eliminate HBV virus in the body , therefore it has brought a new hope for the treatment of hepatitis B .