中西医结合心脑血管病杂志
中西醫結閤心腦血管病雜誌
중서의결합심뇌혈관병잡지
Chinese Journal of Integrative Medicine on Cardio/Cerebrovascular Disease
2015年
14期
1596-1597,1598
,共3页
冠心病%心绞痛%银杏达莫注射液%白细胞介素 6%基质金属蛋白酶 9
冠心病%心絞痛%銀杏達莫註射液%白細胞介素 6%基質金屬蛋白酶 9
관심병%심교통%은행체막주사액%백세포개소 6%기질금속단백매 9
coronary heart disease%angina pectoris%Yinxingdamo injection%interleukin 6%matrix metal oproteinase 9
目的：观察银杏达莫注射液对冠心病心绞痛患者血清白细胞介素6(IL 6)和基质金属蛋白酶9(MMP 9)的影响,探讨其治疗冠心病心绞痛的作用机制。方法将120例冠心病心绞痛患者随机分为对照组和观察组,每组60例。对照组给予西医常规治疗,观察组在对照组治疗基础上加用银杏达莫注射液20 mL,加入5%葡萄糖溶液或生理盐水250 mL中静脉输注,每日1次。两组均连续治疗14 d。观察两组患者心绞痛、心电图疗效及治疗前后血清 IL 6和 MMP 9水平变化。结果观察组治疗后心绞痛和心电图疗效均明显优于对照组(P<0.05)。治疗后,两组患者血清 IL 6和 MMP 9水平与治疗前比较均明显下降(P<0.01),观察组患者血清IL 6和MMP 9水平均显著低于对照组,差异有统计学意义(P<0.01)。结论银杏达莫注射液治疗冠心病心绞痛疗效确切,其作用机制可能与降低患者血清 IL 6和 MMP 9水平、抑制炎症反应有关。
目的：觀察銀杏達莫註射液對冠心病心絞痛患者血清白細胞介素6(IL 6)和基質金屬蛋白酶9(MMP 9)的影響,探討其治療冠心病心絞痛的作用機製。方法將120例冠心病心絞痛患者隨機分為對照組和觀察組,每組60例。對照組給予西醫常規治療,觀察組在對照組治療基礎上加用銀杏達莫註射液20 mL,加入5%葡萄糖溶液或生理鹽水250 mL中靜脈輸註,每日1次。兩組均連續治療14 d。觀察兩組患者心絞痛、心電圖療效及治療前後血清 IL 6和 MMP 9水平變化。結果觀察組治療後心絞痛和心電圖療效均明顯優于對照組(P<0.05)。治療後,兩組患者血清 IL 6和 MMP 9水平與治療前比較均明顯下降(P<0.01),觀察組患者血清IL 6和MMP 9水平均顯著低于對照組,差異有統計學意義(P<0.01)。結論銀杏達莫註射液治療冠心病心絞痛療效確切,其作用機製可能與降低患者血清 IL 6和 MMP 9水平、抑製炎癥反應有關。
목적：관찰은행체막주사액대관심병심교통환자혈청백세포개소6(IL 6)화기질금속단백매9(MMP 9)적영향,탐토기치료관심병심교통적작용궤제。방법장120례관심병심교통환자수궤분위대조조화관찰조,매조60례。대조조급여서의상규치료,관찰조재대조조치료기출상가용은행체막주사액20 mL,가입5%포도당용액혹생리염수250 mL중정맥수주,매일1차。량조균련속치료14 d。관찰량조환자심교통、심전도료효급치료전후혈청 IL 6화 MMP 9수평변화。결과관찰조치료후심교통화심전도료효균명현우우대조조(P<0.05)。치료후,량조환자혈청 IL 6화 MMP 9수평여치료전비교균명현하강(P<0.01),관찰조환자혈청IL 6화MMP 9수평균현저저우대조조,차이유통계학의의(P<0.01)。결론은행체막주사액치료관심병심교통료효학절,기작용궤제가능여강저환자혈청 IL 6화 MMP 9수평、억제염증반응유관。
Objective To study influence of Yinxingdamo injection on interleukin (IL) 6 and matrix metal oproteinase (MMP) 9 in pa-tients with angina pectoris of,and to explore the mechanism.Methods One hundred and twenty patients with angina pectoris were randomly divided into two groups:The control group(n=60)treated with routine treatment,and the treatment group(n=60)treated with routine treatment plus Yinxingdamo injection for 14 days.The effects of angina pectoris and electrocardiogram curative were ob-served.The levels of serum IL 6 and MMP 9 were measured before and after treatment.Results After treatment,the effects of an-gina pectoris and electrocardiogram curative in the treatment group were significantly higher than that in control group (P<0.05). The levels of serum IL 6 and MMP 9 in the treatment group were lower than that in the control group (P<0.01).Conclusion Yinx-ingdamo injection has effect in patients with angina pectoris,which can reduce serum IL 6 and MMP 9 and inhibit inflammatory reaction.
