CAJ | 학술논문

目的：探讨非布司他治疗急性痛风性关节炎对患者血清尿酸（SUA）水平及氧化应激的影响。方法：选取2014年2月-2015年5月我院门诊收治的未经降尿酸治疗的急性痛风性关节炎患者87例，按随机数字表法分为观察组（n=45）和对照组（n=42），分别给予非布司他80 mg/d和别嘌呤醇300 mg/d，口服治疗，3次/d，疗程为24周。比较两组患者治疗期间SUA水平及氧化应激标志物8-羟基脱氧鸟苷（8-OHdG）和3-硝基络氨酸修饰蛋白（3-NT）水平的变化。结果：与治疗前相比，两组患者治疗后SUA、8-OHdG均明显降低（P＜0.05），而3-NT无显著性差异（P＞0.05），组间SUA、8-OHdG变化幅度比较，差异无统计学意义（P＞0.05）；Spearmen相关性分析，8-OHdG水平与SUA呈明显正相关（r=0.620, P＜0.05）。结论：非布司他可有效降低急性痛风性关节炎患者SUA水平，改善患者氧化应激状态，可广泛应用于临床。
목적：탐토비포사타치료급성통풍성관절염대환자혈청뇨산（SUA）수평급양화응격적영향。방법：선취2014년2월-2015년5월아원문진수치적미경강뇨산치료적급성통풍성관절염환자87례，안수궤수자표법분위관찰조（n=45）화대조조（n=42），분별급여비포사타80 mg/d화별표령순300 mg/d，구복치료，3차/d，료정위24주。비교량조환자치료기간SUA수평급양화응격표지물8-간기탈양조감（8-OHdG）화3-초기락안산수식단백（3-NT）수평적변화。결과：여치료전상비，량조환자치료후SUA、8-OHdG균명현강저（P＜0.05），이3-NT무현저성차이（P＞0.05），조간SUA、8-OHdG변화폭도비교，차이무통계학의의（P＞0.05）；Spearmen상관성분석，8-OHdG수평여SUA정명현정상관（r=0.620, P＜0.05）。결론：비포사타가유효강저급성통풍성관절염환자SUA수평，개선환자양화응격상태，가엄범응용우림상。
Objective: To discuss the effect of febuxostat on serum uric acid(SUA) levels and oxidative stress in the treatment of patients with acute gouty arthritis.Methods: Eighty-seven cases of patients with acute gouty arthritis were selected and randomly divided into an observational group (n=45) and a control group (n=42), 80 mg/d of febuxostat was given in the observational group and 300 mg/d of allopurinol in the control group by oral, tid for 24 weeks. The changes of SUA, 8-OHdG, 3-NT levels were compared between two groups.Results: The serum levels of SUA and 8-OHdG in all patients were signiifcantly lower after treatment than before (P<0.05), and there was no signiifcant difference in 3-NT levels (P>0.05). The comparison of the changes of serum levels of SUA and 8-OHdG showed no signiifcant difference between two groups (P>0.05). The analysis of Spearmen correlation showed that 8-OHdG was positively correlated with SUA(r=0.620,P<0.05).Conclusion: Febuxostat can effectively reduce the SUA levels of patients with acute gouty arthritis, improve the state of oxidative stress and can be widely used in clinic.