中国医学前沿杂志（电子版）
中國醫學前沿雜誌（電子版）
중국의학전연잡지（전자판）
Chinese Journal of the Frontiers of Medical Science (Electronic Version)
2015年
9期
33-35
,共3页
糖尿病%胰岛素泵%多次皮下注射胰岛素
糖尿病%胰島素泵%多次皮下註射胰島素
당뇨병%이도소빙%다차피하주사이도소
Diabetes mellitus%Insulin pump%Multiple subcutaneous insulin injection
目的：观察胰岛素泵与多次皮下注射胰岛素治疗重症糖尿病的效果与安全性。方法将120例重症糖尿病患者随机分为观察组与对照组，每组各60例。观察组患者采用胰岛素泵持续皮下输注重组人胰岛素注射液治疗，对照组患者采用重组人胰岛素注射及甘精胰岛素强化治疗，比较治疗前后两组患者血糖水平变化、维持达标血糖胰岛素用量、血糖达标时间和低血糖发生情况。结果治疗前两组患者空腹血糖（FPG）、餐后2小时血糖（2hPG）及睡前血糖水平比较差异均无显著性（P＞0.05），治疗后上述指标均显著下降，两组间比较差异均具有显著性（P＜0.05）。观察组患者血糖达标时间短于对照组，维持达标血糖胰岛素用量低于对照组（P＜0.05）。两组患者低血糖发生率比较差异具有显著性（χ2＝3.96，P＝0.009）。结论胰岛素泵与多次皮下注射胰岛素对重症糖尿病患者的血糖控制均具有较好的疗效和安全性，但胰岛素泵更利于患者血糖控制和减少并发症。
目的：觀察胰島素泵與多次皮下註射胰島素治療重癥糖尿病的效果與安全性。方法將120例重癥糖尿病患者隨機分為觀察組與對照組，每組各60例。觀察組患者採用胰島素泵持續皮下輸註重組人胰島素註射液治療，對照組患者採用重組人胰島素註射及甘精胰島素彊化治療，比較治療前後兩組患者血糖水平變化、維持達標血糖胰島素用量、血糖達標時間和低血糖髮生情況。結果治療前兩組患者空腹血糖（FPG）、餐後2小時血糖（2hPG）及睡前血糖水平比較差異均無顯著性（P＞0.05），治療後上述指標均顯著下降，兩組間比較差異均具有顯著性（P＜0.05）。觀察組患者血糖達標時間短于對照組，維持達標血糖胰島素用量低于對照組（P＜0.05）。兩組患者低血糖髮生率比較差異具有顯著性（χ2＝3.96，P＝0.009）。結論胰島素泵與多次皮下註射胰島素對重癥糖尿病患者的血糖控製均具有較好的療效和安全性，但胰島素泵更利于患者血糖控製和減少併髮癥。
목적：관찰이도소빙여다차피하주사이도소치료중증당뇨병적효과여안전성。방법장120례중증당뇨병환자수궤분위관찰조여대조조，매조각60례。관찰조환자채용이도소빙지속피하수주중조인이도소주사액치료，대조조환자채용중조인이도소주사급감정이도소강화치료，비교치료전후량조환자혈당수평변화、유지체표혈당이도소용량、혈당체표시간화저혈당발생정황。결과치료전량조환자공복혈당（FPG）、찬후2소시혈당（2hPG）급수전혈당수평비교차이균무현저성（P＞0.05），치료후상술지표균현저하강，량조간비교차이균구유현저성（P＜0.05）。관찰조환자혈당체표시간단우대조조，유지체표혈당이도소용량저우대조조（P＜0.05）。량조환자저혈당발생솔비교차이구유현저성（χ2＝3.96，P＝0.009）。결론이도소빙여다차피하주사이도소대중증당뇨병환자적혈당공제균구유교호적료효화안전성，단이도소빙경리우환자혈당공제화감소병발증。
ObjectiveTo observe the clinical efifcacy and safety of continuous subcutaneous insulin infusion (CSII) and multiple subcutaneous insulin injection (MSII) in the treatment of server diabetes.Method120 patients with server diabetes mellitus were selected and randomly divided into observation group and control group, 60 cases in each group, observation group patients were treated with CSII, and control group patients were treated with MSII. Change of blood-glucose, standard time of blood-glucose, insulin dosage of maintaining standard blood-glucose and incidence rate of hypoglycemia were contrasted between the two groups.Result The levels of fasting blood-glucose (FPG), 2 hours postprandial blood glucose (2hPG) and bedtime blood glucose had no signiifcant differences between the two groups before treatment (P>0.05), and these indexes were decreased in the two groups after treatment, the difference was significant between the two groups (P<0.05). The standard time of blood-glucose was shorter and insulin dosage of maintaining standard blood-glucose was lower in observation group than control group (P<0.05), and the incidence rate of hypoglycemia was signiifcant different between the two groups (χ2=3.96,P=0.009).ConclusionBoth CSII and MSII have well curative effect and security in the treatment of server diabetes mellitus, but CSII is preponderant in controlling blood-glucose and decreasing complications.
