CAJ | 학술논문

目的：探讨结缔组织病合并间质性肺病（CTD-ILD）的临床、影像学特征与转归的关系。方法回顾性分析2008年2月～2015年2月我院住院治疗的28例CTD-ILD患者的临床资料，总结其原发病、高分辨率CT（HRCT）特征、激素治疗与转归的关系。结果28例CTD-ILD患者中，无肌病皮肌炎合并间质性肺病（ADM-ILD）3例，死亡2例，预后较差。HRCT表现为普通型间质性肺炎（UIP）4期改变随访无明显进展者预后相对较好；非普通型间质性肺炎（Non-UIP）中急性间质性肺炎（AIP）样改变者预后差。HRCT前3期改变者，部分患者激素治疗有效，1期疗效优于2期。结论对结缔组织病合并间质性肺病患者，可根据结缔组织病类型结合HRCT表现指导激素治疗，提高对预后的判断能力，改善预后。
목적：탐토결체조직병합병간질성폐병（CTD-ILD）적림상、영상학특정여전귀적관계。방법회고성분석2008년2월～2015년2월아원주원치료적28례CTD-ILD환자적림상자료，총결기원발병、고분변솔CT（HRCT）특정、격소치료여전귀적관계。결과28례CTD-ILD환자중，무기병피기염합병간질성폐병（ADM-ILD）3례，사망2례，예후교차。HRCT표현위보통형간질성폐염（UIP）4기개변수방무명현진전자예후상대교호；비보통형간질성폐염（Non-UIP）중급성간질성폐염（AIP）양개변자예후차。HRCT전3기개변자，부분환자격소치료유효，1기료효우우2기。결론대결체조직병합병간질성폐병환자，가근거결체조직병류형결합HRCT표현지도격소치료，제고대예후적판단능력，개선예후。
Objective To study the correlation between the clinical, imaging characteristics with the outcome of patients with connective tissue disease-related interstitial lung disease (CTD-ILD). Methods Selected 28 cases of CTD-ILD patients clinical date from February 2008 to February 2015 in our hospital, to evaluated the correlation between the original disease, high-resolution computed tomography characteristics, hormone therapy and the clinical outcome. Results 28 cases of CTD-ILD patients, 3 patients with interstitial lung disease due to amyopathic dermatomyositis (ADM-ILD), 2 patients was dead and the prognosis were poor. The cases which HRCT characterized with usual interstitial pneumonia (UIP) in fourth-phase have almost no change over the two years follow-up period. The non-UIP cases which HRCT characterized with acute interstitial pneumonia (AIP) image changing have poor prognosis. Some cases which HRCT characterized with the 1, 2, 3 phase image changing were effect with the hormone treatment. The efficiency of 1 phase is better than 2 phase. Conclusion The hormone treatment for the CTD-LID patients can base on the original connective tissue disease and the HRCT characteristics, which is valuable to improve the prognosis.