中国实验动物学报
中國實驗動物學報
중국실험동물학보
Acta Laboratorium Animalis Scientia Sinica
2015年
5期
535-538
,共4页
李迎霞%关东升%任德启%郭健%吴川杰
李迎霞%關東升%任德啟%郭健%吳川傑
리영하%관동승%임덕계%곽건%오천걸
多发性硬化%实验性自身免疫性脑脊髓炎%模型,动物
多髮性硬化%實驗性自身免疫性腦脊髓炎%模型,動物
다발성경화%실험성자신면역성뇌척수염%모형,동물
Multiple sclerosis%Experimental autoimmune encephalomyelitis%Models%animal
实验性自身免疫性脑脊髓炎( experimental autoimmune encephalomyelitis ,EAE)是多发性硬化的实验动物模型,经过近2个多世纪的发展,已可以在猴、大鼠、小鼠等动物制备EAE模型,在同一种品系动物采用不同免疫抗原制备的EAE模型在敏感性和临床特点具有多样性. 本研究就EAE的发展史和目前不同品系实验动物、不同抗原制备EAE模型的特点做一述评,对未来EAE模型的发展前景进行探讨.
實驗性自身免疫性腦脊髓炎( experimental autoimmune encephalomyelitis ,EAE)是多髮性硬化的實驗動物模型,經過近2箇多世紀的髮展,已可以在猴、大鼠、小鼠等動物製備EAE模型,在同一種品繫動物採用不同免疫抗原製備的EAE模型在敏感性和臨床特點具有多樣性. 本研究就EAE的髮展史和目前不同品繫實驗動物、不同抗原製備EAE模型的特點做一述評,對未來EAE模型的髮展前景進行探討.
실험성자신면역성뇌척수염( experimental autoimmune encephalomyelitis ,EAE)시다발성경화적실험동물모형,경과근2개다세기적발전,이가이재후、대서、소서등동물제비EAE모형,재동일충품계동물채용불동면역항원제비적EAE모형재민감성화림상특점구유다양성. 본연구취EAE적발전사화목전불동품계실험동물、불동항원제비EAE모형적특점주일술평,대미래EAE모형적발전전경진행탐토.
Experimental autoimmune encephalomyelitis ( EAE ) is a classic animal model for multiple sclerosis . After more than 2 centuries of development , EAE can be established in mice , monkeys and rats ,etc.Some animals can be immunized by different immune antigens which have different features in sensibility and clinical characteristics .In this pa-per, we will review the development of EAE , discuss the characteristics of EAE models produced by immunization of differ-ent animals with different antigens .In summary, we explore the development of animal models of EAE .
