CAJ | 학술논문

Kinesin-2蛋白是Kinesin超级蛋白家族的一个亚家族,成员包括KIF3A, KIF3B, KIF3C以及KIF17.作为分子马达蛋白,Kinesin-2家族成员参与了细胞内多种蛋白复合体及囊泡的运输,对细胞行使各种生物学功能非常重要. 近年来发现Kinesin-2在纤毛内物质运输方面发挥重要作用,其功能缺陷可导致纤毛发育异常,进而影响组织器官的发育,并最终导致多种纤毛疾病的形成. 本综述将对近期Kinesin-2的研究进展进行介绍,将着重介绍kinesin-2家族成员在模式生物研究中的新进展.
Kinesin-2단백시Kinesin초급단백가족적일개아가족,성원포괄KIF3A, KIF3B, KIF3C이급KIF17.작위분자마체단백,Kinesin-2가족성원삼여료세포내다충단백복합체급낭포적운수,대세포행사각충생물학공능비상중요. 근년래발현Kinesin-2재섬모내물질운수방면발휘중요작용,기공능결함가도치섬모발육이상,진이영향조직기관적발육,병최종도치다충섬모질병적형성. 본종술장대근기Kinesin-2적연구진전진행개소,장착중개소kinesin-2가족성원재모식생물연구중적신진전.
Kinesin-2 family proteins, including KIF3A, KIF3B, KIF3C and KIF17, are members of the kinesin superfamily motor proteins , which transport various proteins and vesicles in the cell and play diverse biological functions . Recently, studies on members of kinesin-2 family proteins suggest that they play fundamental roles during ciliary transport , whose defects can lead to abnormal cilia development , the major cause of human ciliopathies .In this review , we will sum-marize the functions of this motor protein family during ciliogenesis and focus mainly on their roles in the development of model organisms .