中国中西医结合皮肤性病学杂志
中國中西醫結閤皮膚性病學雜誌
중국중서의결합피부성병학잡지
Chinese Journal of Dermatovenerology of Integrated Traditional and Western Medicine
2015年
5期
285-286
,共2页
银屑病关节炎%辅助性T细胞17%调节性T细胞
銀屑病關節炎%輔助性T細胞17%調節性T細胞
은설병관절염%보조성T세포17%조절성T세포
Psoriasis arthritis%T helper 17 Cells%Regulatory T cell
目的 检测老年患者银屑病性关节炎(PsA)外周血中Th17/Treg以及相关细胞因子IL-17、TGF-β1的表达情况,研究在PsA发病中的作用. 方法 收集36例PsA患者作为研究对象,同时收集健康人群30例作为对照组. 流式细胞术检测外周血Th17细胞和CD4+CD25+Treg细胞亚群,酶联免疫吸附法(ELISA)检测IL-17、TGF-β1的水平.结果 Th17在PsA患者外周血中表达高于对照组(P<0.05),Treg在PsA患者和对照组比较差异无统计学意义(P>0.05);PsA患者血清中IL-17表达明显高于对照组(P<0.05),TGF-β1表达水平显著低于对照组(P<0.05). 结论 Th17/Treg细胞相关的细胞因子IL-17、TGF-β1表达异常参与了PsA的发病过程.
目的 檢測老年患者銀屑病性關節炎(PsA)外週血中Th17/Treg以及相關細胞因子IL-17、TGF-β1的錶達情況,研究在PsA髮病中的作用. 方法 收集36例PsA患者作為研究對象,同時收集健康人群30例作為對照組. 流式細胞術檢測外週血Th17細胞和CD4+CD25+Treg細胞亞群,酶聯免疫吸附法(ELISA)檢測IL-17、TGF-β1的水平.結果 Th17在PsA患者外週血中錶達高于對照組(P<0.05),Treg在PsA患者和對照組比較差異無統計學意義(P>0.05);PsA患者血清中IL-17錶達明顯高于對照組(P<0.05),TGF-β1錶達水平顯著低于對照組(P<0.05). 結論 Th17/Treg細胞相關的細胞因子IL-17、TGF-β1錶達異常參與瞭PsA的髮病過程.
목적 검측노년환자은설병성관절염(PsA)외주혈중Th17/Treg이급상관세포인자IL-17、TGF-β1적표체정황,연구재PsA발병중적작용. 방법 수집36례PsA환자작위연구대상,동시수집건강인군30례작위대조조. 류식세포술검측외주혈Th17세포화CD4+CD25+Treg세포아군,매련면역흡부법(ELISA)검측IL-17、TGF-β1적수평.결과 Th17재PsA환자외주혈중표체고우대조조(P<0.05),Treg재PsA환자화대조조비교차이무통계학의의(P>0.05);PsA환자혈청중IL-17표체명현고우대조조(P<0.05),TGF-β1표체수평현저저우대조조(P<0.05). 결론 Th17/Treg세포상관적세포인자IL-17、TGF-β1표체이상삼여료PsA적발병과정.
Objective To study the alteration and its significance of cytokines interleukin(IL)-17, tumor growth factor(TGF)-β1 associated with Th17/Treg cell in psoriasis arthritis(PSA). Methods 36 patients with psoriasis arthritis were observed and 30 healthy people were enrolled as controls. The frequencies of Th17,Treg in peripheral blood were detected by flow cytometric analysis. IL-17 and TGF-β1 were detected by enzyme-linked immunosorbent assay (ELISA). Results The levels of Th17 in peripheral blood were significantly increased in PsA compared with controls. There was no statistical difference between the two groups. Treg IL-17 were significantly increased in patients compared with that in controls (P<0.05). TGF-βwas decreased compared with controls (P<0.05). Conclusion Th17/Treg and its cytokines IL-17,TGF-β1 might play a roles in the pathogenesis of PsA.
