CAJ | 학술논문

目的建立子宫内膜异位症小鼠模型,观察子宫内膜异位症对模型小鼠妊娠能力的影响. 方法通过"腹腔+皮下"同系异体子宫内膜注射法建立子宫内膜异位症小鼠模型,与假手术组、空白组比较,观察其妊娠率及活胎率,观察子宫内膜异位症对模型小鼠妊娠能力的影响. 结果建模2周后,小鼠皮下和腹腔均见有子宫内膜异位病灶生成,模型组、假手术组和空白组,共三组. 通过生育功能检测,三组妊娠率差异有显著性意义(P<0.05). 三组的活胎数差异有显著性意义(P<0.05). 结论成功建立子宫内膜异位症小鼠模型,并证实子宫内膜异位症可影响模型小鼠生育功能.
목적 건립자궁내막이위증소서모형,관찰자궁내막이위증대모형소서임신능력적영향. 방법통과"복강+피하"동계이체자궁내막주사법건립자궁내막이위증소서모형,여가수술조、공백조비교,관찰기임신솔급활태솔,관찰자궁내막이위증대모형소서임신능력적영향. 결과 건모2주후,소서피하화복강균견유자궁내막이위병조생성,모형조、가수술조화공백조,공삼조. 통과생육공능검측,삼조임신솔차이유현저성의의(P<0.05). 삼조적활태수차이유현저성의의(P<0.05). 결론 성공건립자궁내막이위증소서모형,병증실자궁내막이위증가영향모형소서생육공능.
Objectives The aim of the study was to establish a mouse model of endometriosis , and to observe the effects of endometriosis on the reproductive ability in the mice .Methods The mouse models of endometriosis was estab-lished by subcutaneous and intraperitoneal injection of heterogenous endometrium .The pregnancy rate and live embryo number in the experimental , sham operation and blank groups were observed and compared , and the effects of endometrio-sis on reproductive ability of the mice were evaluated .Results Two weeks after the establishment of the mouse model of endometriosis , there were lesions in the peritoneal cavity and subcutaneous tissue of the mice .Compared the pregnancy rates among the model group , sham operation group and blank group , the differences were statistically significant ( P<0.05).Compared the live embryo number in the three groups , there were also significant differences (P<0.05).Con-clusions A mouse model of endometriosis is successfully established , and it demonstrates that endometriosis may affect the reproductive ability of mice .