中国中西医结合皮肤性病学杂志
中國中西醫結閤皮膚性病學雜誌
중국중서의결합피부성병학잡지
Chinese Journal of Dermatovenerology of Integrated Traditional and Western Medicine
2015年
5期
273-275
,共3页
阿达木单抗%银屑病%VDR基因多态性%CDX2
阿達木單抗%銀屑病%VDR基因多態性%CDX2
아체목단항%은설병%VDR기인다태성%CDX2
Adalimumab%Psoriasis%Vitamin D receptor gene%CDX2
目的 探讨维生素D受体(VDR)基因位点多态性与阿达木单抗治疗斑块型银屑病疗效的关联性,以期对生物制剂治疗银屑病效果进行预测.方法 采用中高通量单核苷酸多态性(SNP)分型技术,对达到和未达到银屑病面积与严重程度指数改善75%(PASI75) 的2组患者VDR基因CDX2(rs11568820) 位点多态性进行检测, 比较2组CDX2基因型和等位基因分布频率差异. 结果 有效组和无效组VDR基因CDX2位点的基因型和等位基因的分布频率相比差异均无统计学意义(P>0.05). 结论 VDR基因CDX2位点多态性与阿达木单抗治疗中重度斑块型银屑病疗效无相关性.
目的 探討維生素D受體(VDR)基因位點多態性與阿達木單抗治療斑塊型銀屑病療效的關聯性,以期對生物製劑治療銀屑病效果進行預測.方法 採用中高通量單覈苷痠多態性(SNP)分型技術,對達到和未達到銀屑病麵積與嚴重程度指數改善75%(PASI75) 的2組患者VDR基因CDX2(rs11568820) 位點多態性進行檢測, 比較2組CDX2基因型和等位基因分佈頻率差異. 結果 有效組和無效組VDR基因CDX2位點的基因型和等位基因的分佈頻率相比差異均無統計學意義(P>0.05). 結論 VDR基因CDX2位點多態性與阿達木單抗治療中重度斑塊型銀屑病療效無相關性.
목적 탐토유생소D수체(VDR)기인위점다태성여아체목단항치료반괴형은설병료효적관련성,이기대생물제제치료은설병효과진행예측.방법 채용중고통량단핵감산다태성(SNP)분형기술,대체도화미체도은설병면적여엄중정도지수개선75%(PASI75) 적2조환자VDR기인CDX2(rs11568820) 위점다태성진행검측, 비교2조CDX2기인형화등위기인분포빈솔차이. 결과 유효조화무효조VDR기인CDX2위점적기인형화등위기인적분포빈솔상비차이균무통계학의의(P>0.05). 결론 VDR기인CDX2위점다태성여아체목단항치료중중도반괴형은설병료효무상관성.
Objective To study the association between vitamin D receptor (VDR) gene CDX2 polymorphism and response to Adalimumab treatment of plaque psoriasis, in order to predict the outcomes of biologics in treating psoriasis. Methods By high-throughput SNP sequencing technique, the SNPs of VDR gene locus CDX2 of two groups of patients who were divided by whether they've achieved PASI75 after 12 weeks' treatment were examined. And the allelic frequencies and genotypic frequencies between the two groups were compared byχ2 test. Results The allelic frequencies and genotypic frequencies of VDR gene locus CDX2 between the two groups had no statistical significance (P>0.05). Conclusion There is no association between vitamin D receptor gene CDX2 polymorphism and response to Adalimumab treatment of plaque psoriasis.
