中国实验动物学报
中國實驗動物學報
중국실험동물학보
Acta Laboratorium Animalis Scientia Sinica
2015年
5期
506-508,512
,共4页
崔煦然%刘钊%张志斌%钟菊迎
崔煦然%劉釗%張誌斌%鐘菊迎
최후연%류쇠%장지빈%종국영
脑梗死面积率%行为学评分%脑血流量%大鼠
腦梗死麵積率%行為學評分%腦血流量%大鼠
뇌경사면적솔%행위학평분%뇌혈류량%대서
Infarct area%Behavioral score%Cerebral blood flow%Rats
目的 分析评价线栓法制备大鼠大脑中动脉阻塞模型成功的三种方法之间的相关性,为评价该模型提供一种新的方法和标准. 方法 雄性SD大鼠共(30)只,随机分成假手术组(n =15)、模型组(n=15) ,参照Zea-Longa线栓法稍加改进制备局灶性脑缺血模型,于术前术后检测各组大鼠脑血流变化. 以大鼠脑梗死面积率为金标准,分析该标准与脑血流变化之间的相关性. 结果 模型大鼠脑梗死面积率与脑血流变化量呈正相关,与行为学评分高低无关. 结论 大鼠脑血流量变化可作为评价局灶性脑缺血模型成功的标准.
目的 分析評價線栓法製備大鼠大腦中動脈阻塞模型成功的三種方法之間的相關性,為評價該模型提供一種新的方法和標準. 方法 雄性SD大鼠共(30)隻,隨機分成假手術組(n =15)、模型組(n=15) ,參照Zea-Longa線栓法稍加改進製備跼竈性腦缺血模型,于術前術後檢測各組大鼠腦血流變化. 以大鼠腦梗死麵積率為金標準,分析該標準與腦血流變化之間的相關性. 結果 模型大鼠腦梗死麵積率與腦血流變化量呈正相關,與行為學評分高低無關. 結論 大鼠腦血流量變化可作為評價跼竈性腦缺血模型成功的標準.
목적 분석평개선전법제비대서대뇌중동맥조새모형성공적삼충방법지간적상관성,위평개해모형제공일충신적방법화표준. 방법 웅성SD대서공(30)지,수궤분성가수술조(n =15)、모형조(n=15) ,삼조Zea-Longa선전법초가개진제비국조성뇌결혈모형,우술전술후검측각조대서뇌혈류변화. 이대서뇌경사면적솔위금표준,분석해표준여뇌혈류변화지간적상관성. 결과 모형대서뇌경사면적솔여뇌혈류변화량정정상관,여행위학평분고저무관. 결론 대서뇌혈류량변화가작위평개국조성뇌결혈모형성공적표준.
Objective To analyze the correlation between three evaluation methods of middle cerebral artery occlu -sion and focal cerebral ischemia , and to explore a new method and standard for the evaluation of the model .Method Thirty healthy adult male SD rats were randomly divided into a sham-operated group ( n=20 ) and model group .According to Zea-Longa procedure ,we established the disease model to detect the changes in cerebral blood flow before and after sur -gery.The resulted cerebral infarction area was taken as gold standards .Then we analyzed the correlation between the standards and the changes in cerebral blood flow .Results The changes of infarction area ratio were positively correlated with the changes of cerebral blood flow in the model rats .Conclusions The changes of rat cerebral blood flow can be used to evaluate whether the cerebral ischemia model is successful or not .
