CAJ | 학술논문

目的探讨麝香保心丸对一次性力竭运动大鼠心肌损伤标记物和C反应蛋白的影响. 方法选择雄性Wistar大鼠52只,随机分成实验组和对照组,每组26只. 两组大鼠每天自由进食饮水相同,实验组大鼠每天麝香保心丸2粒(每粒22.5 mg)分2次灌胃,共两周. 两组均接受力竭游泳运动,制成力竭运动动物模型,分别测定和比较两组大鼠血清和心肌组织肌酸激酶(CK)、肌酸激酶同工酶(CK-MB)、肌钙蛋白T(TnT)、B型脑钠肽(BNP)和C反应蛋白(CRP)水平. 结果大鼠平均力竭运动游泳时间实验组较对照组明显延长(P<0.01). 实验组血清和心肌组织CK、CK-MB、TnT、BNP和CRP水平均明显低于对照组( P<0.05). 结论麝香保心丸可显著降低力竭运动大鼠血清和心肌中CK、CK-MB、TnT、BNP和CRP水平,能够减轻力竭运动后心肌损伤.
목적 탐토사향보심환대일차성력갈운동대서심기손상표기물화C반응단백적영향. 방법 선택웅성Wistar대서52지,수궤분성실험조화대조조,매조26지. 량조대서매천자유진식음수상동,실험조대서매천사향보심환2립(매립22.5 mg)분2차관위,공량주. 량조균접수력갈유영운동,제성력갈운동동물모형,분별측정화비교량조대서혈청화심기조직기산격매(CK)、기산격매동공매(CK-MB)、기개단백T(TnT)、B형뇌납태(BNP)화C반응단백(CRP)수평. 결과 대서평균력갈운동유영시간실험조교대조조명현연장(P<0.01). 실험조혈청화심기조직CK、CK-MB、TnT、BNP화CRP수평균명현저우대조조( P<0.05). 결론 사향보심환가현저강저력갈운동대서혈청화심기중CK、CK-MB、TnT、BNP화CRP수평,능구감경력갈운동후심기손상.
Objective To observe the influence of a Chinese traditional medicine , Shexiangbaoxinwan , on myo-cardial injury markers and C-reactive protein in exhaustively exercised rats .Methods A total of 52 male 11-12 week old Wistar rats were divided randomly into two groups:the experimental (n=26) and control groups (n =26).The two groups of rats took food and water freely .The experimental group of rats was given Shexiangbaoxinwan ( 2 capsules per day ) for two weeks.Following a single bout of exhaustive swimming (≥2 hrs), the serum and myocardial CK , CK-MB, TnT, BNP and CRP in both groups were determined and compared .Results Compared with the control group , the exhaustive swim-ming time of the experimental group was significantly prolonged (P<0.01).The levels of serum and myocardial CK , CK-MB, TnT, BNP and CRP in the experimental group were significantly lower than those in the control group ( P<0.05 for all) .Conclusions The Chinese traditional medicine Shexiangbaoxinwan can significantly decrease the levels of rat serum and myocardial CK , CK-MB, TnT, BNP and CRP after a single bout of exhaustive swimming , and car alleviate myocardial injury.