中华胃肠外科杂志
中華胃腸外科雜誌
중화위장외과잡지
Chinese Journal of Gastrointestinal Surgery
2015年
10期
1051-1055
,共5页
高云鹤%崔建新%郗洪庆%申伟松%张珂诚%李佶阳%梁文全%胡翀%卫勃%陈凛
高雲鶴%崔建新%郗洪慶%申偉鬆%張珂誠%李佶暘%樑文全%鬍翀%衛勃%陳凜
고운학%최건신%치홍경%신위송%장가성%리길양%량문전%호충%위발%진름
胃肿瘤%胰岛素样生长因子受体-1%预后%Meta分析
胃腫瘤%胰島素樣生長因子受體-1%預後%Meta分析
위종류%이도소양생장인자수체-1%예후%Meta분석
Stomach neoplasms%Insulin-like growth factor receptor type I%Prognosis,Meta-analysis
目的:系统评价胰岛素样生长因子受体1﹙IGF-1R)的表达与胃癌患者临床病理因素及预后的关系。方法计算机检索Pubmed、EMBASE、Web of Science、CNKI、万方数据库和维普数据库等发表的有关IGF-1R在胃癌组织中的表达及与患者预后的研究;采用Stata 12.0软件进行Meta分析,文献方法学评价参照“欧洲肺癌工作组对肺癌预后因子的评价标准”,文献质量采用纽卡斯尔-渥太华量表来评价。结果共纳入相关文献4篇,累计病例685例。Meta分析结果显示,IGF-1R表达与胃癌肿瘤TNM分期﹙OR=5.20,95%CI:1.12~24.15,P=0.035)、淋巴结转移﹙OR=8.24,95%CI:2.68~25.34,P=0.000)、远处转移﹙OR=17.34,95%CI:6.52~46.15,P=0.000)有关;IGF-1R高表达患者预后明显劣于低表达者﹙HR=2.63,95%CI:1.29~5.40,Z=2.64,P=0.008)。结论 IGF-1R高表达胃癌患者的预后更差。
目的:繫統評價胰島素樣生長因子受體1﹙IGF-1R)的錶達與胃癌患者臨床病理因素及預後的關繫。方法計算機檢索Pubmed、EMBASE、Web of Science、CNKI、萬方數據庫和維普數據庫等髮錶的有關IGF-1R在胃癌組織中的錶達及與患者預後的研究;採用Stata 12.0軟件進行Meta分析,文獻方法學評價參照“歐洲肺癌工作組對肺癌預後因子的評價標準”,文獻質量採用紐卡斯爾-渥太華量錶來評價。結果共納入相關文獻4篇,纍計病例685例。Meta分析結果顯示,IGF-1R錶達與胃癌腫瘤TNM分期﹙OR=5.20,95%CI:1.12~24.15,P=0.035)、淋巴結轉移﹙OR=8.24,95%CI:2.68~25.34,P=0.000)、遠處轉移﹙OR=17.34,95%CI:6.52~46.15,P=0.000)有關;IGF-1R高錶達患者預後明顯劣于低錶達者﹙HR=2.63,95%CI:1.29~5.40,Z=2.64,P=0.008)。結論 IGF-1R高錶達胃癌患者的預後更差。
목적:계통평개이도소양생장인자수체1﹙IGF-1R)적표체여위암환자림상병리인소급예후적관계。방법계산궤검색Pubmed、EMBASE、Web of Science、CNKI、만방수거고화유보수거고등발표적유관IGF-1R재위암조직중적표체급여환자예후적연구;채용Stata 12.0연건진행Meta분석,문헌방법학평개삼조“구주폐암공작조대폐암예후인자적평개표준”,문헌질량채용뉴잡사이-악태화량표래평개。결과공납입상관문헌4편,루계병례685례。Meta분석결과현시,IGF-1R표체여위암종류TNM분기﹙OR=5.20,95%CI:1.12~24.15,P=0.035)、림파결전이﹙OR=8.24,95%CI:2.68~25.34,P=0.000)、원처전이﹙OR=17.34,95%CI:6.52~46.15,P=0.000)유관;IGF-1R고표체환자예후명현렬우저표체자﹙HR=2.63,95%CI:1.29~5.40,Z=2.64,P=0.008)。결론 IGF-1R고표체위암환자적예후경차。
Objective To systemically evaluate the relationship between the expression of insulin-like growth factor receptor type I ﹙IGF-1R) and prognosis in gastric cancer ﹙GC) patients. Methods A literature search was conducted from PubMed, EMBASE, Web of Science, CNKI, Wanfang and VIP databases to retrieve the clinical studies relevant to IGF-1R expression and its prognostic value in GC patients. Meta-analysis was performed using STATA 12.0 software. The methodology was assessed according to the European Lung Cancer Working Party Quality Scale for Biological Prognostic Factors for Lung Cancer. The quality of studies was assessed using the Newcastle-Ottawa scale. Results Four eligible studies including 685 patients were enrolled for this meta-analysis. Analysis results suggested that up-regulation of IGF-1R in GC patients was significantly associated with TNM staging ﹙OR=5.20, 95%CI:1.12 to 24.15, P=0.035), lymph node metastasis ﹙OR=8.24, 95%CI:2.68 to 25.34, P=0.000) and distant metastasis﹙OR=17.34, 95%CI:6.52 to 46.15, P=0.000). Moreover, up-regulated IGF-1R expression was significantly associated with poor overall survival of gastric cancer patients﹙HR=2.63, 95%CI:1.29 to 5.40, Z=2.64, P=0.008). Conclusion High IGF-1R expression may be an adverse prognostic factor in gastric cancer patients.