中华胃肠外科杂志
中華胃腸外科雜誌
중화위장외과잡지
Chinese Journal of Gastrointestinal Surgery
2015年
10期
974-978
,共5页
结直肠肿瘤%辅助化疗%新辅助放化疗%预后
結直腸腫瘤%輔助化療%新輔助放化療%預後
결직장종류%보조화료%신보조방화료%예후
Colorectal neoplasms%Adjuvant chemotherapy%Neoadjuvant chemoradiotherapy%Prognosis
结直肠癌的诊断和治疗是胃肠外科医师的主要工作之一。掌握结直肠癌手术后的辅助治疗,对许多胃肠外科医师至关重要。近年来,随着多项临床试验的开展和新药物的不断出现,结直肠癌的辅助化疗目前已经形成了以氟尿嘧啶药物为主联合奥沙利铂的方案。在当前的各种指南和规范中,Ⅲ期结肠癌是辅助化疗的指征,而Ⅱ期结肠癌是否需要接受辅助化疗尚无定论。另一方面,直肠癌的辅助治疗则缺乏足够的循证医学证据,尤其新辅助治疗后的直肠癌患者化疗的适应证仍存在很大争议。结直肠癌的辅助治疗仍需要开展进一步研究。
結直腸癌的診斷和治療是胃腸外科醫師的主要工作之一。掌握結直腸癌手術後的輔助治療,對許多胃腸外科醫師至關重要。近年來,隨著多項臨床試驗的開展和新藥物的不斷齣現,結直腸癌的輔助化療目前已經形成瞭以氟尿嘧啶藥物為主聯閤奧沙利鉑的方案。在噹前的各種指南和規範中,Ⅲ期結腸癌是輔助化療的指徵,而Ⅱ期結腸癌是否需要接受輔助化療尚無定論。另一方麵,直腸癌的輔助治療則缺乏足夠的循證醫學證據,尤其新輔助治療後的直腸癌患者化療的適應證仍存在很大爭議。結直腸癌的輔助治療仍需要開展進一步研究。
결직장암적진단화치료시위장외과의사적주요공작지일。장악결직장암수술후적보조치료,대허다위장외과의사지관중요。근년래,수착다항림상시험적개전화신약물적불단출현,결직장암적보조화료목전이경형성료이불뇨밀정약물위주연합오사리박적방안。재당전적각충지남화규범중,Ⅲ기결장암시보조화료적지정,이Ⅱ기결장암시부수요접수보조화료상무정론。령일방면,직장암적보조치료칙결핍족구적순증의학증거,우기신보조치료후적직장암환자화료적괄응증잉존재흔대쟁의。결직장암적보조치료잉수요개전진일보연구。
The diagnosis and treatment of colorectal cancer is one of the main diseases of gastrointestinal surgeons. It is very important to master the adjuvant chemotherapy of colorectal cancer for gastrointestinal surgeons. In recent years, with the development of a number of clinical trials and the appearance of new drugs, fluorouracil combined with oxaliplatin had been established as the standard regimen of adjuvant chemotherapy for colorectal cancer. In the current guidelines, stage Ⅲ colon cancer is the indication for adjuvant chemotherapy, while stageⅡ colon cancer should receive adjuvant chemotherapy is uncertain. Unlike colon cancer, adjuvant therapy of rectal cancer is not evidence-based. Especially, the indication and duration of adjuvant chemotherapy for rectal cancer after neoadjuvant chemoradiotherapy remain controversial. Adjuvant therapy of colorectal cancer still needs further investigation.
