中国医药科学
中國醫藥科學
중국의약과학
China Medicine and Pharmacy
2015年
17期
101-103
,共3页
依达拉奉%尤瑞克林%急性脑梗死%血液流变%VEGF%NO
依達拉奉%尤瑞剋林%急性腦梗死%血液流變%VEGF%NO
의체랍봉%우서극림%급성뇌경사%혈액류변%VEGF%NO
Edaravone%Uribe Brooklyn%Acute cerebral infarction%Blood rheology%VEGF%NO
目的 探讨联合应用依达拉奉、尤瑞克林在53例急性脑梗死中的治疗效果及其对血液流变学、血管内皮细胞功能的影响.方法 2012年5月~ 2014年1月我院共收治急性脑梗死患者105例,并随机分为对照组(n=52)和观察组(n=53).两组均接受常规基础治疗,在此基础上,对照组给予单纯依达拉奉治疗,观察组给予依达拉奉、尤瑞克林联合治疗,对比两组的临床治疗效果、血液流变和血管内皮细胞功能情况.结果 观察组治疗总疗效为92.5%,显著高于对照组的76.9%(P<0.05).治疗后,观察组在血浆黏度、低切全血黏度、高切全血黏度、纤维蛋白原和红细胞压积等指标上均显著地低于对照组(P<0.05).治疗后,观察组的NO水平、VEGF水平显著高于对照组(P<0.05).两组治疗中、治疗后没有出现不良反应.结论联合应用依达拉奉、尤瑞克林的疗效显著,能有效地改善患者血液流变学的各项指标,提高血清NO水平、VEGF水平,值得推广应用.
目的 探討聯閤應用依達拉奉、尤瑞剋林在53例急性腦梗死中的治療效果及其對血液流變學、血管內皮細胞功能的影響.方法 2012年5月~ 2014年1月我院共收治急性腦梗死患者105例,併隨機分為對照組(n=52)和觀察組(n=53).兩組均接受常規基礎治療,在此基礎上,對照組給予單純依達拉奉治療,觀察組給予依達拉奉、尤瑞剋林聯閤治療,對比兩組的臨床治療效果、血液流變和血管內皮細胞功能情況.結果 觀察組治療總療效為92.5%,顯著高于對照組的76.9%(P<0.05).治療後,觀察組在血漿黏度、低切全血黏度、高切全血黏度、纖維蛋白原和紅細胞壓積等指標上均顯著地低于對照組(P<0.05).治療後,觀察組的NO水平、VEGF水平顯著高于對照組(P<0.05).兩組治療中、治療後沒有齣現不良反應.結論聯閤應用依達拉奉、尤瑞剋林的療效顯著,能有效地改善患者血液流變學的各項指標,提高血清NO水平、VEGF水平,值得推廣應用.
목적 탐토연합응용의체랍봉、우서극림재53례급성뇌경사중적치료효과급기대혈액류변학、혈관내피세포공능적영향.방법 2012년5월~ 2014년1월아원공수치급성뇌경사환자105례,병수궤분위대조조(n=52)화관찰조(n=53).량조균접수상규기출치료,재차기출상,대조조급여단순의체랍봉치료,관찰조급여의체랍봉、우서극림연합치료,대비량조적림상치료효과、혈액류변화혈관내피세포공능정황.결과 관찰조치료총료효위92.5%,현저고우대조조적76.9%(P<0.05).치료후,관찰조재혈장점도、저절전혈점도、고절전혈점도、섬유단백원화홍세포압적등지표상균현저지저우대조조(P<0.05).치료후,관찰조적NO수평、VEGF수평현저고우대조조(P<0.05).량조치료중、치료후몰유출현불량반응.결론연합응용의체랍봉、우서극림적료효현저,능유효지개선환자혈액류변학적각항지표,제고혈청NO수평、VEGF수평,치득추엄응용.
Objective To explore the curative effect of edaravone combined with uribe brooklyn in treating 53 cases of acute cerebral infarction and on hemorheology and vascular endothelial cell function.MethodsDuring the period from 2012 May to 2014 January 105 cases of acute cerebral infarction patients were treated in our hospital and randomly divided into control group (n=52) and observation group(n=53).The two groups were given conventional treatment.The control group was treated with edaravone,and observation group was given edaravone combined with uribe brooklyn.The clinical treatment effect,blood rheology and vascular endothelial cell function of two groups were compared.ResultsThe total effective rate of observation group was 92.5%,significantly higher than that of the control group 76.9% (P<0.05).After treatment,the plasma viscosity,low shear blood viscosity,high blood viscosity,fibrinogen and hematocrit of the observation group were significantly lower than those of the control group (P<0.05).After treatment,NO level and VEGF level of the observation group were significantly higher than those of control group(P<0.05).There were no adverse reactions in two groups.ConclusionEdaravone combined with uribe brooklyn has a significant effect,can effectively improve the indexes of blood rheology,increase the level of serum NO,VEGF levels,and is worthy of popularization and application.
