CAJ | 학술논문

目的：比较两种方法统计的菌株对抗菌药物不敏感率的差异，评估不考虑菌株临床背景对细菌耐药程度的影响。方法采用两种方法（方法1：基于所有临床分离菌株的方法；方法2：基于与感染相关非重复病原菌的方法）收集某院2008、2010、2013年每年上半年分离的不动杆菌属细菌和金黄色葡萄球菌，比较不同方法收集的菌株对抗菌药物的不敏感率。结果不动杆菌属细菌对各抗菌药物的不敏感率：方法1的统计结果普遍高于方法2，两种方法统计的不敏感率绝对差值为10．46％～33．77％；金黄色葡萄球菌对各抗菌药物的不敏感率：除2010、2013年的复方磺胺甲口恶唑（差值分别为6．17％、10．21％），以及2013年的青霉素 G（差值3．86％）、红霉素（差值2．71％）、阿奇霉素（差值为2．43％）外，方法1的统计结果普遍高于方法2，两种方法统计的不敏感率绝对差值为0～18．04％。结论两种方法统计的菌株对抗菌药物不敏感率均存在偏差，其中不动杆菌属细菌统计结果偏差较大。不考虑菌株临床背景的情况，对细菌耐药性进行评估，可能会高估其耐药程度。
목적：비교량충방법통계적균주대항균약물불민감솔적차이，평고불고필균주림상배경대세균내약정도적영향。방법채용량충방법（방법1：기우소유림상분리균주적방법；방법2：기우여감염상관비중복병원균적방법）수집모원2008、2010、2013년매년상반년분리적불동간균속세균화금황색포도구균，비교불동방법수집적균주대항균약물적불민감솔。결과불동간균속세균대각항균약물적불민감솔：방법1적통계결과보편고우방법2，량충방법통계적불민감솔절대차치위10．46％～33．77％；금황색포도구균대각항균약물적불민감솔：제2010、2013년적복방광알갑구악서（차치분별위6．17％、10．21％），이급2013년적청매소 G（차치3．86％）、홍매소（차치2．71％）、아기매소（차치위2．43％）외，방법1적통계결과보편고우방법2，량충방법통계적불민감솔절대차치위0～18．04％。결론량충방법통계적균주대항균약물불민감솔균존재편차，기중불동간균속세균통계결과편차교대。불고필균주림상배경적정황，대세균내약성진행평고，가능회고고기내약정도。
Objective To compare the differences between two statistical methods for evaluating non-sensitivity of pathogenic bacteria to antimicrobial agents,and explore effect of non-consideration of clinical background on evalua-ting extent of bacterial resistance.Methods Data of Staphylococcus aureus and Acinetobacter spp .in a hospital in the first half year of 2008,2010 and 2013 were collected and conducted statistical analysis with two methods (me-thod 1 :based on all clinically isolated bacteria;method 2 :based on infection-related non-repetitive bacteria),two methods for evaluating bacterial non-sensitive rates to antimicrobial agents were compared.Results The non-sensi-tive rates of Acinetobacter spp .to various antimicrobial agents :statistical results by using method 1 were generally higher than those using method 2,absolute difference between two statistical methods was 10.46%-33.77%;the non-sensitive rates of Staphylococcus aureus to various antimicrobial agents :except compound sulfamethoxazole in 2010 and 2013(difference were 6.17% and 10.21 % respectively),penicillin G (difference was 3.86%),erythromy-cin (difference was 2.71 %),and azithromycin in 2013 (difference was 2.43%),statistical results by using method 1 were generally higher than those using method 2,absolute difference between two statistical methods was 0-18.04%.Conclusion There are deviation in the non-sensitive rates of bacterial strains to antimicrobial agents by using two different statistical methods,deviation is larger in Acinetobacter spp ..The resistance level might be incorrectly higher when evaluating the resistance status without considering clinical background of bacteria.