中国医药科学
中國醫藥科學
중국의약과학
China Medicine and Pharmacy
2015年
17期
110-112
,共3页
多索茶碱%布地奈德%支气管哮喘%氨茶碱
多索茶堿%佈地奈德%支氣管哮喘%氨茶堿
다색다감%포지내덕%지기관효천%안다감
Doxofylline%Budesonide%Bronchial asthma%aminophylline
目的 探讨多索茶碱联合布地奈德治疗支气管哮喘的临床疗效.方法 回顾性分析2012年12月~2014年12月我院接诊的支气管哮喘住院患者102例临床资料,根据治疗方法将所有患者分为两组,其中50例患者给予雾化布地奈德作为对照组,观察组为52例采用多索茶碱联合布地奈德治疗的患者.对比两组患者的治疗效果、FEV1、FVC、PEF及不良反应发生情况.结果 两组患者采用不同治疗方法治疗后,观察组总有效率为94.23%明显高于对照组总有效率82.00%,差异有统计学意义(x2=5.096,P<0.05).治疗前两组患者的肺功能差异无统计学意义(P>0.05),治疗后两组患者肺功能及PaO2、PaCO2均有明显改善,差异有统计学意义(P<0.05),且观察组FEV1/FVC及PaO2、PaCO2均明显优于对照组,差异有统计学意义(P<0.05).治疗后,观察组患者不良反应发生率为13.47%,明显少于对照组患者不良反应发生率34.00%,差异有统计学意义(x2=6.526,P<0.05).结论 多索茶碱联合布地奈德治疗支气管哮喘能够改善患者的呼吸功能,效果显著,安全性高.
目的 探討多索茶堿聯閤佈地奈德治療支氣管哮喘的臨床療效.方法 迴顧性分析2012年12月~2014年12月我院接診的支氣管哮喘住院患者102例臨床資料,根據治療方法將所有患者分為兩組,其中50例患者給予霧化佈地奈德作為對照組,觀察組為52例採用多索茶堿聯閤佈地奈德治療的患者.對比兩組患者的治療效果、FEV1、FVC、PEF及不良反應髮生情況.結果 兩組患者採用不同治療方法治療後,觀察組總有效率為94.23%明顯高于對照組總有效率82.00%,差異有統計學意義(x2=5.096,P<0.05).治療前兩組患者的肺功能差異無統計學意義(P>0.05),治療後兩組患者肺功能及PaO2、PaCO2均有明顯改善,差異有統計學意義(P<0.05),且觀察組FEV1/FVC及PaO2、PaCO2均明顯優于對照組,差異有統計學意義(P<0.05).治療後,觀察組患者不良反應髮生率為13.47%,明顯少于對照組患者不良反應髮生率34.00%,差異有統計學意義(x2=6.526,P<0.05).結論 多索茶堿聯閤佈地奈德治療支氣管哮喘能夠改善患者的呼吸功能,效果顯著,安全性高.
목적 탐토다색다감연합포지내덕치료지기관효천적림상료효.방법 회고성분석2012년12월~2014년12월아원접진적지기관효천주원환자102례림상자료,근거치료방법장소유환자분위량조,기중50례환자급여무화포지내덕작위대조조,관찰조위52례채용다색다감연합포지내덕치료적환자.대비량조환자적치료효과、FEV1、FVC、PEF급불량반응발생정황.결과 량조환자채용불동치료방법치료후,관찰조총유효솔위94.23%명현고우대조조총유효솔82.00%,차이유통계학의의(x2=5.096,P<0.05).치료전량조환자적폐공능차이무통계학의의(P>0.05),치료후량조환자폐공능급PaO2、PaCO2균유명현개선,차이유통계학의의(P<0.05),차관찰조FEV1/FVC급PaO2、PaCO2균명현우우대조조,차이유통계학의의(P<0.05).치료후,관찰조환자불량반응발생솔위13.47%,명현소우대조조환자불량반응발생솔34.00%,차이유통계학의의(x2=6.526,P<0.05).결론 다색다감연합포지내덕치료지기관효천능구개선환자적호흡공능,효과현저,안전성고.
Objective To investigate the clinical curative effect of doxofylline combined with budesonide for bronchial asthma.Methods The clinical data of 102 patients with bronchial asthma were retrospectively analyzed,who were in hospital from December 2012 to December 2014,and divided into two groups according to the treatment method.50 patients were given budesonide as control group,and observation group of 52 cases were treated with doxofylline combined with budesonide.ResultsAfter different treatment methods of two groups,the total effective rate of observation group was 94.23%,significantly higher than that of the control group 82.00%.The difference was statistically significant(x2=5.096,P<0.05).Of the two groups were observed,and adverse reactions were compared.Before treatment,the lung function of two groups had no significant difference(P>0.05).After treatment,pulmonary function and PaO2,PaCO2 of two groups were significantly improved(P<0.05),and the observation group FEV1/FVC,PaCO2 and PaO2 were significantly better than that of the control group,the difference was statistically significant (P<0.05).The adverse reaction rate of observation group was 13.47%,significantly less than that of the control group of 34.00%,with the statistical significance differences(x2=6.526,P<0.05).Conclusion Doxofylline combined with budesonide in the treatment of bronchial asthma can improve respiratory function.It is obvious effect and higher safely.
