CAJ | 학술논문

随着辅助生殖技术(assisted reproductive technology,ART)的迅速发展,全世界通过该技术出生的孩子数量已经达到500万以上.ART作为治疗不孕不育问题的主要手段,其子代健康一直受到关注.ART的相关操作技术及患者本身因素可能会引起其子代表观遗传改变,从而导致相关疾病的发生.本文中我们对ART子代出现的疾病如印记综合征、代谢综合征、癌症等进行归纳,分析其与表观遗传的联系,从表观遗传角度探讨ART子代疾病的发病机制,有助于评价ART对其子代的影响和应用安全性.
수착보조생식기술(assisted reproductive technology,ART)적신속발전,전세계통과해기술출생적해자수량이경체도500만이상.ART작위치료불잉불육문제적주요수단,기자대건강일직수도관주.ART적상관조작기술급환자본신인소가능회인기기자대표관유전개변,종이도치상관질병적발생.본문중아문대ART자대출현적질병여인기종합정、대사종합정、암증등진행귀납,분석기여표관유전적련계,종표관유전각도탐토ART자대질병적발병궤제,유조우평개ART대기자대적영향화응용안전성.
The number of offspring conceived by assisted reproductive technology (ART) has reached over 5 million.As the primary means for treating infertility,the health of offspring produced by ART has been a long concern.Both procedures of ART and factors underlying infertility can lead to epigenetic changes which can cause certain diseases.This paper has reviewed diseases noted among offspring conceived by ART,which include imprinting disorders,metabolic syndromes and cancers.We also tried to explore the pathogenesis of such diseases from an epigenetic perspective,which may help with evaluation the influence of ART on the offspring and its safety for application.