CAJ | 학술논문

当前，肿瘤疾病以日益增高的发病率越来越受到人们的重视。抑制P53-MDM2的相互作用已经成为治疗癌症药物设计的重要靶标，通过各种药物筛选手段，研究人员发现了许多肽类及小分子抑制剂。综述近年来国内外关于肽类及拟肽类的P53-MDM2抑制剂的研究进展。
당전，종류질병이일익증고적발병솔월래월수도인문적중시。억제P53-MDM2적상호작용이경성위치료암증약물설계적중요파표，통과각충약물사선수단，연구인원발현료허다태류급소분자억제제。종술근년래국내외관우태류급의태류적P53-MDM2억제제적연구진전。
Tumor diseases have attracted great attention of the society because of the increasing morbidity in recent years .To inhibit the P53-MDM2 interaction has become an important target for design of cancer drug ,and a lot of peptide and small molecule inhibitors have been found with various kinds of drug screening and research tools .This paper summarized the recent progress of the peptide and peptidomimetic inhibitors of P53-MDM2 at home and abroad lately .