CAJ | 학술논문

炭疽是由炭疽杆菌引起的人畜共患的传染病。炭疽杆菌属于需氧芽孢杆菌属，为G＋菌，其病原体是芽孢。炭疽芽孢最外层含有特定结构的四糖抗原，可用于制备糖缀合物疫苗，诱导免疫反应。综述近10年来文献报道对炭疽四糖化学合成的研究进展，并结合国内外最新研究成果介绍各条制备路线，比较各种方法的主要优缺点。
탄저시유탄저간균인기적인축공환적전염병。탄저간균속우수양아포간균속，위G＋균，기병원체시아포。탄저아포최외층함유특정결구적사당항원，가용우제비당철합물역묘，유도면역반응。종술근10년래문헌보도대탄저사당화학합성적연구진전，병결합국내외최신연구성과개소각조제비로선，비교각충방법적주요우결점。
Objective Anthrax is an anthropozoonosis caused by the bacterium Bacillus anthracis .Bacillus anthracis is an aerobic ,spore-forming ,rod-shaped bacterium ,which infects human through ingestion or inhalation of the spores .The exos-porium of spores of Bacillus anthracis contains tetrasaccharide antigen with specific chemical structure ,which can be used in preparation of glycoconjugates vaccines ,inducing an immune response .This paper reviewed articles in the last decade that re-ported research advances in chemical synthesis of anthrax tetrasaccharide ,presented the methods for synthesis ,and compared the advantages and limitations among different methods .