CAJ | 학술논문

目的：探讨小剂量黛立新联合复方阿嗪米特治疗功能性消化不良并心理障碍的疗效及安全性。方法选取100例功能性消化不良并心理障碍患者，随机分为观察组（n=50）和对照组（n=50）。对照组给予复方阿嗪米特治疗，观察组给予小剂量黛立新联合复方阿嗪米特治疗，连续4周。比较两组患者症状评分、临床疗效、汉密尔顿抑郁量表（hamilton depression scale, HAMD）评分及汉密尔顿焦虑量表（hamilton anxiety scale, HAMA）评分。结果治疗后，观察组患者嗳气、反酸、上腹饱胀及上腹疼痛等症状评分分别为（1.1±0.2）分、（1.1±0.3）分、（1.3±0.3）分、（1.4±0.2）分，对照组分别为（1.8±0.3）分、（1.7±0.2）分、（2.2±0.3）分、（2.1±0.3）分，观察组评分显著低于对照组，组间比较差异具有统计学意义（P＜0.05）。观察组HAMD、HAMA评分分别为（7.1±1.2）分、（6.7±1.2）分，对照组分别为（12.7±2.3）分、（10.9±2.0）分，观察组评分显著低于对照组，组间比较差异具有统计学意义（P＜0.05）。观察组和对照组治疗有效率分别为94.0%（47/50）、74.0%（37/50），组间比较具有统计学意义（P＜0.05）。两组均未发生严重不良反应。结论小剂量黛立新联合复方阿嗪米特治疗功能性消化不良并心理障碍，可显著改善患者焦虑、抑郁情绪，缓解功能性消化不良症状，提高临床疗效，其效果优于单纯复方阿嗪米特治疗。
목적：탐토소제량대립신연합복방아진미특치료공능성소화불량병심리장애적료효급안전성。방법선취100례공능성소화불량병심리장애환자，수궤분위관찰조（n=50）화대조조（n=50）。대조조급여복방아진미특치료，관찰조급여소제량대립신연합복방아진미특치료，련속4주。비교량조환자증상평분、림상료효、한밀이돈억욱량표（hamilton depression scale, HAMD）평분급한밀이돈초필량표（hamilton anxiety scale, HAMA）평분。결과치료후，관찰조환자애기、반산、상복포창급상복동통등증상평분분별위（1.1±0.2）분、（1.1±0.3）분、（1.3±0.3）분、（1.4±0.2）분，대조조분별위（1.8±0.3）분、（1.7±0.2）분、（2.2±0.3）분、（2.1±0.3）분，관찰조평분현저저우대조조，조간비교차이구유통계학의의（P＜0.05）。관찰조HAMD、HAMA평분분별위（7.1±1.2）분、（6.7±1.2）분，대조조분별위（12.7±2.3）분、（10.9±2.0）분，관찰조평분현저저우대조조，조간비교차이구유통계학의의（P＜0.05）。관찰조화대조조치료유효솔분별위94.0%（47/50）、74.0%（37/50），조간비교구유통계학의의（P＜0.05）。량조균미발생엄중불량반응。결론소제량대립신연합복방아진미특치료공능성소화불량병심리장애，가현저개선환자초필、억욱정서，완해공능성소화불량증상，제고림상료효，기효과우우단순복방아진미특치료。
Objective To evaluate the safety and efficacy of small-dose of flupentixol and melitracen combined with compound azintamide on patients with functional dyspepsia and psycho-disturbance. Methods One hundred patients with functional dyspepsia and psycho-disturbance were divided into observation group (n=50) and control group (n=50). The compound azintamide was used in control group, and small-dose flu-pentixol and melitracen combined with compound azintamide were used in observation group, for 4 weeks. The symptom score, clinical efficacy, hamilton depression scale (HAMD) score and hamilton anxiety scale (HAMA) score were compared between the two groups. Results The symptom score of belching, reflux, ab-dominal distension and stomachache in observation group was 1.1 ± 0.2, 1.1 ± 0.3,1.3 ± 0.3 and 1.4 ± 0.2, re-spectively; those of control group respectively was 1.8 ± 0.3, 1.7 ± 0.2, 2.2 ± 0.3 and 2.1 ± 0.3 respectively. The symptom score of observation group was significantly lower than control group (P<0.05). The HAMD score and HAMA score of observation group was 7.1 ± 1.2 and 6.7 ± 1.2 respectively, those of control group respectively was 12.7 ± 2.3 and 10.9 ± 2.0. The HAMD score and HAMA score of observation group signifi-cantly lower than control group (P<0.05). The clinical efficacy of observation group and control group was 94.0%(47/50) and 74.0%(37/50) respectively, the clinical efficacy of observation group was significantly high-er than control group(P<0.05). No serious adverse reaction occurred in two groups. Conclusion The small-dose of flupentixol and melitracen combined with compound azintamide treatment on patients with functional dyspepsia and psycho-disturbance could significantly alleviate the anxiety and depression, improve functional dyspepsia symptoms.