CAJ | 학술논문

目的通过分析中药注射剂引发不良反应(ADR)的临床特点及原因,提高中药制剂使用合理性.方法回顾性分析2013年1月~2014年12月1742例给予中药制剂注射治疗的的患者的临床资料,统计ADR发生率,并对ADR发生的危险因素进行Logistic回归分析.结果 49例发生ADR,发生率为2.81%,不同种类中药制剂ADR发生率比较差异无统计学意义(P>0.05);ADR患者以>60岁及≤6岁者居多,分别占34.69%和30.61%;ADR多发生于输液24h内,占65.31%;以皮肤及其附件ADR为主,占30.61%;Logistic回归分析显示,以NaCl作为溶媒、滴速≥60滴/min是ADR发生的危险因素,注射前冲管是ADR发生的保护性因素.结论常用的中药注射剂在各年龄段均有可能引发ADR,临床应注意加强对老年及少儿的监测,选择适宜的溶媒,控制好滴速,输液前严格冲管,以减少ADR发生率.
목적 통과분석중약주사제인발불량반응(ADR)적림상특점급원인,제고중약제제사용합이성.방법 회고성분석2013년1월~2014년12월1742례급여중약제제주사치료적적환자적림상자료,통계ADR발생솔,병대ADR발생적위험인소진행Logistic회귀분석.결과 49례발생ADR,발생솔위2.81%,불동충류중약제제ADR발생솔비교차이무통계학의의(P>0.05);ADR환자이>60세급≤6세자거다,분별점34.69%화30.61%;ADR다발생우수액24h내,점65.31%;이피부급기부건ADR위주,점30.61%;Logistic회귀분석현시,이NaCl작위용매、적속≥60적/min시ADR발생적위험인소,주사전충관시ADR발생적보호성인소.결론 상용적중약주사제재각년령단균유가능인발ADR,림상응주의가강대노년급소인적감측,선택괄의적용매,공제호적속,수액전엄격충관,이감소ADR발생솔.
Objective To investigate clinical characteristics and causes of ADR induced by TCM injections,so as to promote rationality for the use of TCM.Methods A retrospective analysis of clinical data of 1742 cases of patients which treated with TCM injectionin from January 2013 to December 2014,counted ADR incidence,and risk factors for the occurrence of ADR Logistic regression analysis.Results 49 cases of patients occurred ADR,the rate was 2.81%;ADR induced by different TCM was not statistically significant (P>0.05);ADR patients with>60 year-old and≤6 year-old who were mostly aged,accounting for 34.69% and 30.61%;Occurred in the post-infusion 24h,accounting for 65.31%;Involved organ with skin damage,accounting for 30.61%;Logistic regression analysis showed that solvent misuse,drip too fast were independent risk factors for ADR,pediment injection tube was a protective factor for ADR occurred.Conclusion Commonly used in Chinese medicine for injection are likely to lead to ADR,clinical should pay attention to strengthening the monitoring of the elderly and the children,choose a suitable vehicle,control the drip rate,before infusion tight red tube,in order to reduce the incidence of ADR.