中国医学前沿杂志（电子版）
中國醫學前沿雜誌（電子版）
중국의학전연잡지（전자판）
Chinese Journal of the Frontiers of Medical Science (Electronic Version)
2015年
9期
124-127
,共4页
张昆%邹梅%张蓉%韩智晓%苏相飞
張昆%鄒梅%張蓉%韓智曉%囌相飛
장곤%추매%장용%한지효%소상비
氟比洛芬酯注射液%硫酸吗啡缓释片%癌痛
氟比洛芬酯註射液%硫痠嗎啡緩釋片%癌痛
불비락분지주사액%류산마배완석편%암통
Flurbiprofen axetil injection%Morphine sulfate sustained release tablets%Cancer pain
目的：研究氟比洛芬酯注射液联合硫酸吗啡缓释片对中、重度癌痛患者疼痛及生活质量的影响。方法将本院94例中、重度癌痛患者随机分为观察组及对照组。观察组患者采取氟比洛芬酯联合硫酸吗啡缓释片治疗，对照组患者采取硫酸吗啡缓释片治疗。比较治疗后两组患者视觉模拟评分法（VAS）评分、欧洲癌症研究与治疗组织生活质量测定量表（EORTC QLQ-C30）评分及不良反应发生情况。结果治疗后观察组患者VAS评分明显低于对照组（P＜0.01），疼痛控制率明显高于对照组（P＜0.05）。两组患者EORTC QLQ-C30评分比较，观察组患者功能量表5项评分均高于对照组（P＜0.05），且症状量表及单一症状量表中疼痛及失眠项目评分均低于对照组（P＜0.01），总体健康量表评分明显高于对照组（P＜0.01）。两组患者不良反应发生率比较无明显差异（P＞0.05）。结论氟比洛芬酯注射液联合硫酸吗啡缓释片可有效改善中、重度癌痛患者的临床症状，提高患者生存质量，且不增加不良反应。
目的：研究氟比洛芬酯註射液聯閤硫痠嗎啡緩釋片對中、重度癌痛患者疼痛及生活質量的影響。方法將本院94例中、重度癌痛患者隨機分為觀察組及對照組。觀察組患者採取氟比洛芬酯聯閤硫痠嗎啡緩釋片治療，對照組患者採取硫痠嗎啡緩釋片治療。比較治療後兩組患者視覺模擬評分法（VAS）評分、歐洲癌癥研究與治療組織生活質量測定量錶（EORTC QLQ-C30）評分及不良反應髮生情況。結果治療後觀察組患者VAS評分明顯低于對照組（P＜0.01），疼痛控製率明顯高于對照組（P＜0.05）。兩組患者EORTC QLQ-C30評分比較，觀察組患者功能量錶5項評分均高于對照組（P＜0.05），且癥狀量錶及單一癥狀量錶中疼痛及失眠項目評分均低于對照組（P＜0.01），總體健康量錶評分明顯高于對照組（P＜0.01）。兩組患者不良反應髮生率比較無明顯差異（P＞0.05）。結論氟比洛芬酯註射液聯閤硫痠嗎啡緩釋片可有效改善中、重度癌痛患者的臨床癥狀，提高患者生存質量，且不增加不良反應。
목적：연구불비락분지주사액연합류산마배완석편대중、중도암통환자동통급생활질량적영향。방법장본원94례중、중도암통환자수궤분위관찰조급대조조。관찰조환자채취불비락분지연합류산마배완석편치료，대조조환자채취류산마배완석편치료。비교치료후량조환자시각모의평분법（VAS）평분、구주암증연구여치료조직생활질량측정량표（EORTC QLQ-C30）평분급불량반응발생정황。결과치료후관찰조환자VAS평분명현저우대조조（P＜0.01），동통공제솔명현고우대조조（P＜0.05）。량조환자EORTC QLQ-C30평분비교，관찰조환자공능량표5항평분균고우대조조（P＜0.05），차증상량표급단일증상량표중동통급실면항목평분균저우대조조（P＜0.01），총체건강량표평분명현고우대조조（P＜0.01）。량조환자불량반응발생솔비교무명현차이（P＞0.05）。결론불비락분지주사액연합류산마배완석편가유효개선중、중도암통환자적림상증상，제고환자생존질량，차불증가불량반응。
ObjectiveTo explore the influence of flurbiprofen axetil injection combined with morphine sulfate sustained release tablets in the treatment of patients with moderate or severe cancer pain.Method 94 patients with moderate or severe cancer pain in our hospital were randomly divided into observation group and control group. Patients in observation group were treated with flurbiprofen axetil injection combined with morphine sulfate sustained release tablets, patients in control group were treated with morphine sulfate sustained release tablets. VAS and EORTC QLQ-C30 scores and the occurrence of untoward effect between the two groups after treatment were compared.ResultAfter treatment, VAS scores of observation group were obviously lower than control group (P<0.01); pain control rate of observation group was higher than control group (P<0.05). When the treatment was ifnished, observation group had higher scores than control group in the 5 items of functioning scale (P<0.05), and the scores of pain and insomnia in observation group were both lower than control group (P<0.01); observation group had obviously higher score than control group in general health questionnaire (P<0.01); there was not signiifcant difference between the two groups in occurrence of untoward effect (P>0.05).ConclusionFlurbiprofen axetil injection combined with morphine sulfate sustained release tablets can effectively relieve clinlcal symptom of patients with moderate or severe cancer pain, improvethe quality of life, and it does not increase the untoward effect.
