CAJ | 학술논문

目的探讨18F-FLT与18F-FDG联合显像对孤立性肺结节的诊断价值.方法 A549细胞与两种示踪剂分别进行结合实验,分析两者结合率差异,结合率与Ki-67的相关性.55例肺部SPN患者 18F-FLT、18F-FDGPET/CT联合显像资料,以术后病理为"金标准",分析两种示踪剂对SPN的诊断效能,观察病灶SUV与病理组织Ki-67的相关性.结果 A549细胞对FDG的平均摄取率高于对FLT的平均摄取率(P<0.05),肺癌A549细胞的增殖指数Ki-67与FDG的摄取率无明显的相关性(P>0.05),而与FLT的摄取率有明显的正相关性(r=0.824,P<0.01).18F-FDG诊断肺癌的灵敏度为89%,特异度67%,准确性73%.18F-FLT诊断肺癌的灵敏度为71%、特异度79%、准确性76%.FDG在肺脏孤立性肺结节对示踪剂的摄取优于FLT,FLT对原发性肺癌的显示优于对其他病变的显示,FDG对原发性肺癌和结核的显示优于对感染和良性病变的显示.肺癌组织的增殖指数Ki-67与FDG的摄取率呈明显的正相关性(r=0.658,P<0.05),且与FLT的摄取率有明显的正相关性(r=0.724,P<0.01).结论 A549细胞和SPN对18F-FDG摄取率高于18F-FLT,18F-FLT对肺癌特异性高于 18F-FDG,两种示踪剂的联合使用可以提高肺癌诊断的特异性和准确性.
목적 탐토18F-FLT여18F-FDG연합현상대고립성폐결절적진단개치.방법 A549세포여량충시종제분별진행결합실험,분석량자결합솔차이,결합솔여Ki-67적상관성.55례폐부SPN환자 18F-FLT、18F-FDGPET/CT연합현상자료,이술후병리위"금표준",분석량충시종제대SPN적진단효능,관찰병조SUV여병리조직Ki-67적상관성.결과 A549세포대FDG적평균섭취솔고우대FLT적평균섭취솔(P<0.05),폐암A549세포적증식지수Ki-67여FDG적섭취솔무명현적상관성(P>0.05),이여FLT적섭취솔유명현적정상관성(r=0.824,P<0.01).18F-FDG진단폐암적령민도위89%,특이도67%,준학성73%.18F-FLT진단폐암적령민도위71%、특이도79%、준학성76%.FDG재폐장고립성폐결절대시종제적섭취우우FLT,FLT대원발성폐암적현시우우대기타병변적현시,FDG대원발성폐암화결핵적현시우우대감염화량성병변적현시.폐암조직적증식지수Ki-67여FDG적섭취솔정명현적정상관성(r=0.658,P<0.05),차여FLT적섭취솔유명현적정상관성(r=0.724,P<0.01).결론 A549세포화SPN대18F-FDG섭취솔고우18F-FLT,18F-FLT대폐암특이성고우 18F-FDG,량충시종제적연합사용가이제고폐암진단적특이성화준학성.
Objective To explore the diagnostic value of18F-FLT and18F-FDGin the diagnosis of solitary pulmonary nodules (SPN).Methods A549 cells banded with two tracers experiment respectively in vitro,and cells-tracers binding ratios difference is analyzed,and the correlation of tracers binding ratios with Ki-67is analyzed.Imaging data of 55 patients with SPN who were examined by18F-FLT and18F-FDGPET/CT were collected,with pathological results as the gold standard.We explored the diagnostic value of18F-FLT and18F-FDG in the diagnosis of solitary pulmonary nodules and the correlation of SUV with Ki-67.Results18F-FDG uptake rate of A549 cells is higher than18F-FLT uptake rate (P<0.05).There was no correlation between18F-FDG uptake ratio and proliferation index Ki-67 of A549 cells (P>0.05),but the proliferation index Ki-67 had significant positive correlation with18F-FLT uptake rate (r=0.824,P<0.824).Diagnostic sensitivity of18F-FDGfor lung cancer was 89%,and the specificity was 67%,and accuracy was73%.Diagnostic sensitivity of18F-FLT for lung cancer was 89%,and the specificity was 67%,and accuracy was 73%.18F-FDG uptake ratio of SPN is higher than that18F-FLT ratio,and18F-FLT for primary lung cancer display was superior to for other lesions.18F-FDG for primary lung cancer and tuberculosis display was superior to for infection and benign lesions.There was obviously positive correlation between lung cancer proliferation index of Ki-67 and18F-FDG uptake ratio(r=0.658,P<0.05),and18F-FLT uptake ratio(r=0.724,P<0.01).Conclusion18F-FDG uptake rateofA549 cells and SPN are higher than18F-FLT uptake rate.Diagnostic specificity of18F-FLT for lung cancer is higher than18F-FDG.A combination of two tracers can improve the diagnostic specificity and accuracy of lung cancer.