CAJ | 학술논문

目的：探讨血必净注射液对创伤性凝血病患者的血制品输注及全身炎症状态的影响。方法：共79例患者纳入研究，随机分为治疗组（36例）和对照组（43例）。对照组接受常规治疗，治疗组在此基础上加用血必净注射液。检测两组患者不同时间点的肿瘤坏死因子－α（TNF-α）、白细胞介素－6（IL-6）、白细胞介素－8（IL-8）水平，统计其血制品使用情况，并进行比较。结果：治疗前后比较：两组患者凝血功能的异常基本纠正；组间比较：治疗组输注的红细胞、新鲜冰冻血浆、冷沉淀量少于对照组，差异有统计学意义（P ＜0．05）。收治后72 h，治疗组TNFα、IL-6、IL-8水平低于对照组，差异有统计学意义（P ＜0．05）。结论：血必净注射液可减少创伤性凝血病患者血制品的使用量，考虑与其拮抗全身炎症反应的作用有关。
목적：탐토혈필정주사액대창상성응혈병환자적혈제품수주급전신염증상태적영향。방법：공79례환자납입연구，수궤분위치료조（36례）화대조조（43례）。대조조접수상규치료，치료조재차기출상가용혈필정주사액。검측량조환자불동시간점적종류배사인자－α（TNF-α）、백세포개소－6（IL-6）、백세포개소－8（IL-8）수평，통계기혈제품사용정황，병진행비교。결과：치료전후비교：량조환자응혈공능적이상기본규정；조간비교：치료조수주적홍세포、신선빙동혈장、랭침정량소우대조조，차이유통계학의의（P ＜0．05）。수치후72 h，치료조TNFα、IL-6、IL-8수평저우대조조，차이유통계학의의（P ＜0．05）。결론：혈필정주사액가감소창상성응혈병환자혈제품적사용량，고필여기길항전신염증반응적작용유관。
Objective To study the effect of Xuebijing injection on transfusion and systemic inflammation in traumatic coagulopathy patients. Methods Seventy-nine patients were randomly divided into Xuebijing Group (36 cases) and Control Group (43 cases). Xuebijing group received Xuebijing injection in addition to the regular treatment received by control group. Levels of TNF-α, IL-6, IL-8 and transfusion amount between two groups were compared. Results Coagulation abnormality was almost corrected in all patients after treatment. In Xuebijing Group, transfusion of RBC, FFP and cryoprecipitate were significantly less than that in control group (P<0.05). At 72 h after admission, TNFα, IL-6 and IL-8 were significantly lower in Xuebijing Group (P < 0.05). Conclusion Xuebijing injection could reduce transfusion in traumatic coagulopathy patients , possibly resulting from its antagonism against systemic inflammation.