CAJ | 학술논문

背景 Toll样受体4(toll like receptor 4,TLR4)作为一种模式识别受体,不仅在天然免疫中发挥重要作用,而且可以介导中枢免疫信号导致一系列包括慢性疼痛的中枢神经系统病理反应. 目的对TLR4在神经病理性疼痛(neuropathicpain,NP)发病机制中的作用及其研究进展作一综述. 内容介绍NP、TLR4以及探讨TLR4参与NP的可能机制. 趋向 TLR4可作为缓解或治疗NP的潜在靶点.
배경 Toll양수체4(toll like receptor 4,TLR4)작위일충모식식별수체,불부재천연면역중발휘중요작용,이차가이개도중추면역신호도치일계렬포괄만성동통적중추신경계통병리반응. 목적 대TLR4재신경병이성동통(neuropathicpain,NP)발병궤제중적작용급기연구진전작일종술. 내용 개소NP、TLR4이급탐토TLR4삼여NP적가능궤제. 추향 TLR4가작위완해혹치료NP적잠재파점.
Background As an pattern recognition receptor, toll-like receptor 4(TLR4) not only plays an important role in innate immune system, but also mediates a myriad of central nervous system pathologies including chronic pain.Objective To detect the effect of TLR4 in the mechanisms of neuropathic pain(NP) development.Content The review gives a brief introduction about the neuropathic pain, TLR4 and the possible mechanism of TLR4 involved in NP.Trend The TLR4 pathway may be a potential target of the remission or treatment for NP.