CAJ | 학술논문

目的：探讨免疫固定分型技术在M蛋白相关疾病诊断中的应用价值。方法采用免疫球蛋白定量、血清及尿蛋白电泳、血清及尿本周蛋白免疫固定电泳及其他试验，对2例患者标本进行检测和确认。结果结合实验室检测及患者临床体征，1例患者确诊为血清单克隆Ig A‐κ轻链型多发性骨髓，1例患者确诊为血清Ig M‐λ型巨球蛋白血症。结论随着电泳技术发展，免疫固定电泳分型技术在M蛋白鉴定中具有较高的特异性和敏感性，应加强其临床应用。
목적：탐토면역고정분형기술재M단백상관질병진단중적응용개치。방법채용면역구단백정량、혈청급뇨단백전영、혈청급뇨본주단백면역고정전영급기타시험，대2례환자표본진행검측화학인。결과결합실험실검측급환자림상체정，1례환자학진위혈청단극륭Ig A‐κ경련형다발성골수，1례환자학진위혈청Ig M‐λ형거구단백혈증。결론수착전영기술발전，면역고정전영분형기술재M단백감정중구유교고적특이성화민감성，응가강기림상응용。
Objective To investigate the diagnostic value of immunofixation electrophoresis typing techniques in M protein relat‐ed diseases .Methods Specimens of patients were simultaneously tested and identified by quantitative detection of immunoglobu‐lins ,immunofixation electrophoresis ,and other detections .Results Light chain multiple myeloma of IgA‐κ monoclonal type was i‐dentified in one patient .Macroglobulinemia of IgM‐λtype was identified in the other patient .Conclusion With the development of electrophoresis techniques ,immunofixation electrophoresis technique could be with high sensitivity and specificity in identifying M protein ,which should be widely applied in clinic .