CAJ | 학술논문

目的：探讨不同类型冠状动脉粥样硬化性心脏病（CHD）患者外周血内皮微粒（EMPs）水平变化及其与白细胞介素‐6（IL‐6）和C反应蛋白（CRP）的相关性。方法选择CHD患者38例，分为心肌梗死（MI）组13例、不稳定性心绞痛（UA）组13例、稳定性心绞痛（SA）组12例，以12例健康者作为对照组。采用流式细胞术检测血浆 EMPs水平；采用酶联免疫吸附法和特种蛋白分析仪分别检测血清IL‐6和CRP水平。结果 MI组、UA组 EMPs水平高于SA 组和对照组（P＜0．05）。CHD患者体内EMPs水平与IL‐6、CRP具有显著的相关性（相关系数分别为0．79、0．50，P＜0．05）。结论 EMPs可作为监测和评估CHD患者内皮细胞损伤程度的指标；EM Ps可能通过增强炎性反应性血管损伤而在C HD发生、发展过程中发挥重要作用。
목적：탐토불동류형관상동맥죽양경화성심장병（CHD）환자외주혈내피미립（EMPs）수평변화급기여백세포개소‐6（IL‐6）화C반응단백（CRP）적상관성。방법선택CHD환자38례，분위심기경사（MI）조13례、불은정성심교통（UA）조13례、은정성심교통（SA）조12례，이12례건강자작위대조조。채용류식세포술검측혈장 EMPs수평；채용매련면역흡부법화특충단백분석의분별검측혈청IL‐6화CRP수평。결과 MI조、UA조 EMPs수평고우SA 조화대조조（P＜0．05）。CHD환자체내EMPs수평여IL‐6、CRP구유현저적상관성（상관계수분별위0．79、0．50，P＜0．05）。결론 EMPs가작위감측화평고CHD환자내피세포손상정도적지표；EM Ps가능통과증강염성반응성혈관손상이재C HD발생、발전과정중발휘중요작용。
Objective To investigate alterations of endothelial microparticles(EMPs) levels in patients with coronary heart dis‐ease(CHD) ,and to evaluate the relationship between EMPs and interleukin‐6(IL‐6) and C‐reactive protein(CRP) .Methods A to‐tal of 38 patients with CHD were divided into myocardial infarction(MI) group(13 cases) and unstable angina(UA) group(13 ca‐ses) and stable angina(SA) group(12 cases) ,and 12 healthy subjects were enrolled as control group .Levels of EMPs were meas‐ured by using flow cytometry technique .Concentration of IL‐6 and CRP were determined by using enzyme linked immunosorbent assay and special protein analysis respectively .Results Compared with SA group and control group ,levels of EMPs were signifi‐cantly increased in MI group and UA group(P<0 .05) .Levels of EMPs in patients with CHD were significantly correlated with IL‐6 and CRP ,with correlation coefficient of 0 .79 and 0 .50 respectively(P<0 .05) .Conclusion EMPs could contribute to monitoring and evaluating the degree of endothelial cells injury in patients with CHD as a laboratory indicator .EMPs might enhance the vascu‐lar inflammation in patients with CHD ,and further accelerate the development of CHD .