CAJ | 학술논문

目的：探讨血清钙离子（Ca2＋）、C反应蛋白（CRP）、尿酸（UA）、同型半胱氨酸（Hcy）及补体C3、C4联合检测对妊娠期高血压病（HDCP）的诊断价值。方法以HDCP确诊患者作为HDCP组，以未合并 HDCP的孕妇作为对照组，检测并比较血清Ca2＋、CRP、UA、Hcy及补体C3、C4水平，分析各指标单独检测及联合检测对 HDCP的诊断性能。结果 HDCP组与对照组血清Ca2＋、CRP、UA、Hcy及补体C3、C4水平比较差异有统计学意义（P＜0．05）。6项指标联合检测的灵敏度、符合率及正确诊断率高于各指标单独检测（P＜0．05），但特异度比较差异无统计学意义（P＞0．05）。血清CRP、UA和Hcy水平随着 HDCP患者病情进展逐渐升高，而血清Ca2＋、补体C3和C4水平逐渐降低，且 HDCP患者各亚组间不同指标检测结果比较差异有统计学意义（P＜0．05）。结论早期联合检测血清Ca2＋、CRP、UA、Hcy及补体C3、C4水平对 HDCP的早期诊治和病情评估具有重要意义。
목적：탐토혈청개리자（Ca2＋）、C반응단백（CRP）、뇨산（UA）、동형반광안산（Hcy）급보체C3、C4연합검측대임신기고혈압병（HDCP）적진단개치。방법이HDCP학진환자작위HDCP조，이미합병 HDCP적잉부작위대조조，검측병비교혈청Ca2＋、CRP、UA、Hcy급보체C3、C4수평，분석각지표단독검측급연합검측대 HDCP적진단성능。결과 HDCP조여대조조혈청Ca2＋、CRP、UA、Hcy급보체C3、C4수평비교차이유통계학의의（P＜0．05）。6항지표연합검측적령민도、부합솔급정학진단솔고우각지표단독검측（P＜0．05），단특이도비교차이무통계학의의（P＞0．05）。혈청CRP、UA화Hcy수평수착 HDCP환자병정진전축점승고，이혈청Ca2＋、보체C3화C4수평축점강저，차 HDCP환자각아조간불동지표검측결과비교차이유통계학의의（P＜0．05）。결론조기연합검측혈청Ca2＋、CRP、UA、Hcy급보체C3、C4수평대 HDCP적조기진치화병정평고구유중요의의。
Objective To explore the diagnostic value of combined detection of serum calcium ion (Ca2+ ) ,C‐reaction protein (CRP) ,uric acid(UA) ,homocysteine(Hcy) and complement C3 ,C4 in hypertension disorders complicating pregnancy(HDCP) . Methods Patients with HDCP were enrolled as HDCP group ,and pregnant women without HDCP were enrolled as control group . Serum parameters ,mentioned above ,were detected and compared between the two groups .Diagnostic performance of the parameters was also analyzed .Results Serum levels of Ca2+ ,CRP ,UA ,Hcy and complement C3 ,C4 in HDCP group were significantly differ‐ent from those in control group(P<0 .05) .Sensitivity ,coincidence rate and correct diagnosis rate of combined detection of these six parameters were higher than single detection(P<0 .05) ,but the specificity was without significant difference(P>0 .05) .Serum lev‐els of CRP ,UA and Hcy increased with the progress of HDCP disease condition ,but serum levels of Ca2+ ,C3 and C4 decreased .Be‐tween different sub‐group of HDCP patients ,serum levels of the six parameters were with significant differences(P<0 .05) .Conclu‐sion Early combined detection of serum Ca2+ ,CRP ,UA ,Hcy and complement C3 ,C4 could be with significance for the early diag‐nosis and treatment of HDCP ,and also for the condition assessment of HDCP .