CAJ | 학술논문

目的：探讨幽门螺杆菌（Hp）感染与心肌梗死及脑梗死的相关性，及其与血清同型半胱氨酸（Hcy）水平的相关性。方法选择心肌梗死确诊患者72例、脑梗死确诊患者86例、体检健康者80例，采用酶联免疫吸附法和循环酶法分别检测 H p‐IgG抗体及血清Hcy水平，分析Hp感染与血清 Hcy水平之间的关系。结果心肌梗死患者 Hp‐IgG阳性率及血清 Hcy水平均高于健康者（P＜0．05）；心肌梗死患者中，Hp‐IgG阳性者 Hcy水平高于 Hp阴性者（P＜0．05）。脑梗死患者 Hp‐IgG阳性率与健康者比较差异无统计学意义（P＞0．05）；脑梗死患者中，Hp‐IgG阳性者 Hcy水平与阴性者比较差异无统计学意义（P＞0．05），但脑梗死患者血清Hcy水平高于健康者（P＜0．05）。结论 Hp感染与心肌梗死的发生相关，Hp可能通过影响血清 Hcy水平而诱发心肌梗死。Hp感染与脑梗死的发生无明显相关性，脑梗死患者血清 Hcy水平升高与Hp感染无关。
목적：탐토유문라간균（Hp）감염여심기경사급뇌경사적상관성，급기여혈청동형반광안산（Hcy）수평적상관성。방법선택심기경사학진환자72례、뇌경사학진환자86례、체검건강자80례，채용매련면역흡부법화순배매법분별검측 H p‐IgG항체급혈청Hcy수평，분석Hp감염여혈청 Hcy수평지간적관계。결과심기경사환자 Hp‐IgG양성솔급혈청 Hcy수평균고우건강자（P＜0．05）；심기경사환자중，Hp‐IgG양성자 Hcy수평고우 Hp음성자（P＜0．05）。뇌경사환자 Hp‐IgG양성솔여건강자비교차이무통계학의의（P＞0．05）；뇌경사환자중，Hp‐IgG양성자 Hcy수평여음성자비교차이무통계학의의（P＞0．05），단뇌경사환자혈청Hcy수평고우건강자（P＜0．05）。결론 Hp감염여심기경사적발생상관，Hp가능통과영향혈청 Hcy수평이유발심기경사。Hp감염여뇌경사적발생무명현상관성，뇌경사환자혈청 Hcy수평승고여Hp감염무관。
Objective To investigate correlation between Helicobacter pylori infection and incidence of myocardial infarction and cerebral infarction ,and serum homocysteine(Hcy) level .Methods A total of 72 patients with myocardial infarction ,86 patients with cerebral infarction and 80 healthy subjects were enrolled and detected for Hp‐IgG and serum Hcy by using enzyme‐linked im‐munosorbent assays and enzymatic cycling method .Relationship between Hp infection and serum level of Hcy were analyzed .Results The positive rate of Hp‐IgG and serum Hcy level in patients with myocardial infarction were significantly higher than healthy subjects(P<0 .05) .Among patients with myocardial infarction ,serum level of Hcy in Hp‐IgG positive patients was higher than that in Hp‐IgG negative patients(P<0 .05) .The positive rate of Hp‐IgG between patients with cerebral infarction and healthy subjects was without significant difference(P>0 .05) .Among patients with cerebral infarction ,serum level of Hcy between Hp‐IgG positive patients and Hp‐IgG negative patients were without significant difference(P>0 .05) .But serum Hcy level in patients with cerebral infarction was significantly higher than that in healthy subjects(P<0 .05) .Conclusion Hp infection might promote the occurrence of myocardial infarction by affecting serum level of Hcy .However ,there might be without obvious correlation between Hp infection and the occurrence of cerebral infarction .And there could be no direct association between high serum level of Hcy in patients with cerebral infarction and Hp infection .