CAJ | 학술논문

目的：系统评价GenoType? MTBDRsl试验检测喹诺酮类抗结核药耐药性的准确性。方法检索 PubMed、Em‐base、Web of Science、中国生物医学文献数据库、中国知网、维普数据库和万方数据库，采集以GenoType? M TBDRsl试验作为喹诺酮类抗结核药耐药性检测诊断性试验的文献，对纳入研究进行方法学质量评价后，采用 M eta‐Disc1．4软件进行统计学分析。结果最终纳入16篇文献，共1766例患者。Meta分析结果显示，GenoType? MTBDRsl试验检测喹诺酮类抗结核药耐药性的合并敏感度、合并特异度、阳性似然比、阴性似然比、诊断比值比和综合受试者工作特征曲线下面积分别为0．83、0．96、17．50、0．20、108．46和0．9349。结论 GenoType棆 MTBDRsl试验对喹诺酮类抗结核药耐药性的诊断敏感度和特异度较高，可作为喹诺酮类抗结核药耐药性检测的有效方法之一。
목적：계통평개GenoType? MTBDRsl시험검측규낙동류항결핵약내약성적준학성。방법검색 PubMed、Em‐base、Web of Science、중국생물의학문헌수거고、중국지망、유보수거고화만방수거고，채집이GenoType? M TBDRsl시험작위규낙동류항결핵약내약성검측진단성시험적문헌，대납입연구진행방법학질량평개후，채용 M eta‐Disc1．4연건진행통계학분석。결과최종납입16편문헌，공1766례환자。Meta분석결과현시，GenoType? MTBDRsl시험검측규낙동류항결핵약내약성적합병민감도、합병특이도、양성사연비、음성사연비、진단비치비화종합수시자공작특정곡선하면적분별위0．83、0．96、17．50、0．20、108．46화0．9349。결론 GenoType륜 MTBDRsl시험대규낙동류항결핵약내약성적진단민감도화특이도교고，가작위규낙동류항결핵약내약성검측적유효방법지일。
Objective To evaluate the diagnostic accuracy of GenoType? M TBDRsl for the resistance to fluoroquinolones anti‐tuberculosis drugs .Methods Systematic and comprehensive literature was searched in PubMed ,Embase ,Web of Science ,CBM , CNKI ,VIP and Wanfang database .The relative studies of GenoType? MTBDRsl to fluoroquinolones anti‐tuberculosis drugs were included .After quality assessment ,Meta‐Disc1 .4 software was used to analyze the data .Results A total of 16 trials ,involving 1 766 participants ,were included .The results of Meta‐analysis showed that the weighted sensitivity ,specificity ,positive likelihood ra‐tio ,negative likelihood ratio ,diagnostic odds ratio ,and the area under summary receiver operation curve were 0 .83 ,0 .96 ,17 .50 , 0 .20 ,108 .46 and 0 .934 9 ,respectively .Conclusion GenoType? M TBDRsl assay for the resistance to fluoroquinolones anti‐tuber‐culosis drugs might be with high sensitivity and specificity ,which could be recommended as efficacy diagnostic tool .