CAJ | 학술논문

目的：评估微小RNA‐21（miRNA‐21）对食管癌的诊断价值。方法针对有关miRNA‐21诊断食管癌的文献，进行数据库检索、手工查询。采用QUADAS‐2软件对纳入的文献进行质量评价，采用Meta‐DiSc软件对数据进行分析，并选择相应的效应模型计算汇总灵敏度、特异性、阳性似然比、阴性似然比、诊断优势比。结果筛选获得4篇符合纳入及排除标准的文献，共涉及食管癌患者202例，健康者124例。miRNA‐21诊断食管癌的汇总灵敏度、特异度分别为0．85、0．65，综合受试者工作特征曲线下面积为0．8174。结论 miRNA‐21作为诊断食管癌新指标，可用于食管癌的筛查及辅助诊断。
목적：평고미소RNA‐21（miRNA‐21）대식관암적진단개치。방법침대유관miRNA‐21진단식관암적문헌，진행수거고검색、수공사순。채용QUADAS‐2연건대납입적문헌진행질량평개，채용Meta‐DiSc연건대수거진행분석，병선택상응적효응모형계산회총령민도、특이성、양성사연비、음성사연비、진단우세비。결과사선획득4편부합납입급배제표준적문헌，공섭급식관암환자202례，건강자124례。miRNA‐21진단식관암적회총령민도、특이도분별위0．85、0．65，종합수시자공작특정곡선하면적위0．8174。결론 miRNA‐21작위진단식관암신지표，가용우식관암적사사급보조진단。
Objective To evaluate the performance of microRNA‐21(miRNA‐21) for the diagnosis of esophageal cancer .Meth‐ods Published literatures ,investigating the diagnostic performance of miRNA‐21 in esophageal cancer ,were screened .QUADAS‐2 software was used to evaluate the quality of related literatures .All analysis about relevant data was accomplished by using Meta‐DiSc statistical software .The sensitivity ,specificity ,positive likelihood rate ,negative likelihood rate and diagnostic odds ratio were pooled ,using corresponding effects models .Results Four studies met the inclusion criteria ,accumulating 202 esophageal cancer pa‐tients and 124 healthy controls .The summary estimates for miRNA‐21 in the diagnosis of esophageal cancer were with diagnostic sensitivity of 0 .85 and specificity of 0 .65 .The area under summary receiver operating characteristic curve was 0 .817 4 .Conclusion miRNA‐21 might be a novel biomarker for the diagnosis of esophageal cancer ,and could be used for screening and auxiliary diag‐nosis of esophageal cancer .