吉林医学
吉林醫學
길림의학
Jilin Medical Journal
2015年
17期
3772-3774
,共3页
血清铁蛋白%总铁结合力%冠状动脉狭窄
血清鐵蛋白%總鐵結閤力%冠狀動脈狹窄
혈청철단백%총철결합력%관상동맥협착
Serum Iron%Total Iron Binding Capacity%Coronary Artery Stenosis
目的:体内铁负荷水平与冠心病的发病有一定的相关性,铁负荷与冠心病的其他危险因素在动脉粥样硬化过程中可能具有一定协同作用。本研究通过测定研究对象血清铁蛋白(SF)及总铁结合力(TIBC)浓度来探讨 SF/ TIBC 比值与冠心病发病之间的关系,及该比值与冠心病严重程度相关性。方法:对185例新入院疑似冠心病患者行冠状动脉造影检查,根据 Gensini评分系统对冠脉造影结果评分,将观察对象按照 Gensini 评分结果分为正常冠脉对照组和冠状动脉轻、中、重度病变组,分别检测各组观察对象血清 TIBC、SF、总胆固醇(TC)、三酰甘油(TG)、高密度脂蛋白-胆固醇(HDL - C)、低密度脂蛋白-胆固醇(LDL -C)、血红蛋白(HB)浓度,应用 Kruskal - Wallis H 检验、Student - Newman - Keuls 检验、Tamhane' T2检验和 Spearman 等级相关分析对上述资料进行分析。结果:各组间 LDL - C、HDL - C、SF、TIBC、SF/ TIBC 比值分布差异有统计学意义(P ﹤0.05),SF/ TIBC 比值与 Gensini 积分呈正相关(r =0.589,P ﹤0.01)。结论:SF/ TIBC 比值与冠心病的发病有一定相关性,与冠状动脉狭窄程度呈正相关。
目的:體內鐵負荷水平與冠心病的髮病有一定的相關性,鐵負荷與冠心病的其他危險因素在動脈粥樣硬化過程中可能具有一定協同作用。本研究通過測定研究對象血清鐵蛋白(SF)及總鐵結閤力(TIBC)濃度來探討 SF/ TIBC 比值與冠心病髮病之間的關繫,及該比值與冠心病嚴重程度相關性。方法:對185例新入院疑似冠心病患者行冠狀動脈造影檢查,根據 Gensini評分繫統對冠脈造影結果評分,將觀察對象按照 Gensini 評分結果分為正常冠脈對照組和冠狀動脈輕、中、重度病變組,分彆檢測各組觀察對象血清 TIBC、SF、總膽固醇(TC)、三酰甘油(TG)、高密度脂蛋白-膽固醇(HDL - C)、低密度脂蛋白-膽固醇(LDL -C)、血紅蛋白(HB)濃度,應用 Kruskal - Wallis H 檢驗、Student - Newman - Keuls 檢驗、Tamhane' T2檢驗和 Spearman 等級相關分析對上述資料進行分析。結果:各組間 LDL - C、HDL - C、SF、TIBC、SF/ TIBC 比值分佈差異有統計學意義(P ﹤0.05),SF/ TIBC 比值與 Gensini 積分呈正相關(r =0.589,P ﹤0.01)。結論:SF/ TIBC 比值與冠心病的髮病有一定相關性,與冠狀動脈狹窄程度呈正相關。
목적:체내철부하수평여관심병적발병유일정적상관성,철부하여관심병적기타위험인소재동맥죽양경화과정중가능구유일정협동작용。본연구통과측정연구대상혈청철단백(SF)급총철결합력(TIBC)농도래탐토 SF/ TIBC 비치여관심병발병지간적관계,급해비치여관심병엄중정도상관성。방법:대185례신입원의사관심병환자행관상동맥조영검사,근거 Gensini평분계통대관맥조영결과평분,장관찰대상안조 Gensini 평분결과분위정상관맥대조조화관상동맥경、중、중도병변조,분별검측각조관찰대상혈청 TIBC、SF、총담고순(TC)、삼선감유(TG)、고밀도지단백-담고순(HDL - C)、저밀도지단백-담고순(LDL -C)、혈홍단백(HB)농도,응용 Kruskal - Wallis H 검험、Student - Newman - Keuls 검험、Tamhane' T2검험화 Spearman 등급상관분석대상술자료진행분석。결과:각조간 LDL - C、HDL - C、SF、TIBC、SF/ TIBC 비치분포차이유통계학의의(P ﹤0.05),SF/ TIBC 비치여 Gensini 적분정정상관(r =0.589,P ﹤0.01)。결론:SF/ TIBC 비치여관심병적발병유일정상관성,여관상동맥협착정도정정상관。
Objective To study the relationship between serum ferritin(SF)- to - total iron binding capacity(TIBC)ratio and the se-verity of coronary artery stenosis. Method All of 185 patients suspected coronary heart disease(CHD)underwent coronary angiography and were allocated into control group,mild,moderate and severe group of coronary artery stenosis according to the Gensini score. Levels of SF, TIBC,total cholesterol( TC),triglyceride( TG),high density lipoprotein cholesterol( HDL - C),low density lipoprotein cholesterol (LDL - C),hemoglobin(HB)were examined. The above indexes of the four groups were analyzed by SPSS statistical software and the rela-tionship among SF/ TIBC ratio and Gensini score was further investigated by Spearman's rank correlation analysis. Results The distributions of LDL - C、HDL - C、SF、TIBC、SF/ TIBC ratio among the four groups were significantly different(P ﹤ 0. 05). Spearman's rank correlation analysisshowed that SF/ TIBC ratio was positively correlate with the Gensini score(r = 0. 589,P ﹤ 0. 01). Conclusion SF / TIBC ratio has a correlation with CHD and is positively correlate with the the severity of coronary artery stenosis.