CAJ | 학술논문

背景神经病理性疼痛(neuropathic pain,NP)的形成机制非常复杂,其中免疫炎症对NP的产生和维持非常重要,小胶质细胞作为中枢神经系统(central nervous system,CNS)的免疫活性细胞,已证实其激活与NP密切相关,而且其不同的极化状态(M1/M2)对CNS的免疫环境产生截然不同的损伤或保护作用.有研究发现,促进小胶质细胞M2型极化可抑制多种慢性神经炎性疾病,并在脊髓损伤(spine cord injury,SCI)模型中产生镇痛作用. 目的阐述小胶质细胞M2型极化与NP关系的研究进展. 内容从NP的发病机制,小胶质细胞极化及与神经疾病关系,与NP发生、发展关系等研究进展展开综述.趋向从免疫炎症方面为NP的发病机制及其治疗提供新的思路.
배경 신경병이성동통(neuropathic pain,NP)적형성궤제비상복잡,기중면역염증대NP적산생화유지비상중요,소효질세포작위중추신경계통(central nervous system,CNS)적면역활성세포,이증실기격활여NP밀절상관,이차기불동적겁화상태(M1/M2)대CNS적면역배경산생절연불동적손상혹보호작용.유연구발현,촉진소효질세포M2형겁화가억제다충만성신경염성질병,병재척수손상(spine cord injury,SCI)모형중산생진통작용. 목적천술소효질세포M2형겁화여NP관계적연구진전. 내용종NP적발병궤제,소효질세포겁화급여신경질병관계,여NP발생、발전관계등연구진전전개종술.추향종면역염증방면위NP적발병궤제급기치료제공신적사로.
Background The mechanisms of neuropathic pain (NP) are very complex, and immune inflammation plays an important role in generation and maintenance of NP.As the immune active cells of the central nervous system (CNS), the status of microglia activation M1 and M2 have enormous different influences on whether protective or cytotoxic in the central nervous system immune environment.Recent studies have shown that promoting microglia towards M2 polarization can inhibit a variety of chronic neural inflammatory diseases and produce analgesic role in the spinal cord injury(SCI) model.Objective To describe the research advance regarding relationship of microglia M2 polarization with NP.Content This paper introduces the pathogenesis of NP, microglia polarization and its relationships with neurological disease, and the occurrence and development of NP.Trend To provide a new idea about the pathogenesis and treatment of NP from the immune inflammation aspect.