CAJ | 학술논문

目的：了解分离自重症监护病房（IC U ）送检标本鲍曼不动杆菌的标本来源和耐药性。方法回顾性分析2011～2014年分离自川北医学院附属医院IC U患者临床标本的520株鲍曼不动杆菌的临床分布和耐药性。结果鲍曼不动杆菌主要分离自痰液标本，占90．4％。鲍曼不动杆菌对头孢哌酮／舒巴坦和米诺环素的耐药率相对较低，分别为32．0％和25．2％；对复方磺胺甲噁唑和左旋氧氟沙星的耐药率分别为68．1％和74．9％；对其他常用抗菌药物的耐药率均超过86．0％。结论分离自IC U送检标本的鲍曼不动杆菌对多种抗菌药物耐药率高，对头孢哌酮／舒巴坦和米诺环素的耐药率较低。应加强对鲍曼不动杆菌的耐药性监测，根据药敏实验结果合理选用抗菌药物。
목적：료해분리자중증감호병방（IC U ）송검표본포만불동간균적표본래원화내약성。방법회고성분석2011～2014년분리자천북의학원부속의원IC U환자림상표본적520주포만불동간균적림상분포화내약성。결과포만불동간균주요분리자담액표본，점90．4％。포만불동간균대두포고동／서파탄화미낙배소적내약솔상대교저，분별위32．0％화25．2％；대복방광알갑오서화좌선양불사성적내약솔분별위68．1％화74．9％；대기타상용항균약물적내약솔균초과86．0％。결론분리자IC U송검표본적포만불동간균대다충항균약물내약솔고，대두포고동／서파탄화미낙배소적내약솔교저。응가강대포만불동간균적내약성감측，근거약민실험결과합리선용항균약물。
Objective To investigate the specimen source and antibiotics resistance of Acinetobacter baumannii isolated from in‐patient in Intensive Care Unit(ICU) .Methods Specimen source and antibiotics resistance of 520 strains of Acinetobacter bauman‐nii ,isolated from patients of ICU in Affiliated Hospital of North Sichuan Medical College from 2011 to 2014 ,were retrospectively analyzed .Results The main source of Acinetobacter baumannii was sputum specimens ,accounting for 90 .4% .Acinetobacter bau‐mannii isolates showed the lowest resistance rates to cefoperazone‐sulbactam and minocycline(32 .0% and 25 .2% ,respectively) .A‐bout 68 .1% and 74 .9% of these strains were resistant to trimethoprim‐sulfamethoxazole and levofloxacin ,respectively .More than 86 .0% of the strains were resistant to other tested antibacterial agents .Conclusion Acinetobacter baumanii strains ,isolated from ICU ,could have high resistance rates to many kinds of antibacterial agents ,and cefoperazone‐sulbactam and minocycline might be with fine antibacterial activity against Acinetobacter baumanii .Drug resistance monitoring of Acinetobacter baumanii should be strengthened ,and antibacterial agents should be selected and used rationally according to the results of drug sensitivity test .