国际麻醉学与复苏杂志
國際痳醉學與複囌雜誌
국제마취학여복소잡지
International Journal of Anesthesiology and Resuscitation
2015年
10期
950-952
,共3页
术后镇痛%右美托咪定%α2肾上腺素能受体激动剂
術後鎮痛%右美託咪定%α2腎上腺素能受體激動劑
술후진통%우미탁미정%α2신상선소능수체격동제
Postoperative pain management%Dexmedetomidine%α2 adrenergic receptor agonist
背景 术后疼痛是一种以伤害性疼痛为主的急性疼痛,右美托咪定(dexmedetomidine,Dex)作为一种α2肾上腺素能受体激动剂,与其他镇痛药物联合可以减少其他镇痛药物用量及其副作用. 目的 综述Dex在术后镇痛中的应用进展,为该药在镇痛中的应用提供参考. 内容 从Dex的药理特性、镇痛机制、各种给药途径、副作用等方面综述Dex在术后镇痛治疗中的应用. 趋向 Dex在镇痛方面有广泛的应用前景,但其安全性需要进一步的研究.
揹景 術後疼痛是一種以傷害性疼痛為主的急性疼痛,右美託咪定(dexmedetomidine,Dex)作為一種α2腎上腺素能受體激動劑,與其他鎮痛藥物聯閤可以減少其他鎮痛藥物用量及其副作用. 目的 綜述Dex在術後鎮痛中的應用進展,為該藥在鎮痛中的應用提供參攷. 內容 從Dex的藥理特性、鎮痛機製、各種給藥途徑、副作用等方麵綜述Dex在術後鎮痛治療中的應用. 趨嚮 Dex在鎮痛方麵有廣汎的應用前景,但其安全性需要進一步的研究.
배경 술후동통시일충이상해성동통위주적급성동통,우미탁미정(dexmedetomidine,Dex)작위일충α2신상선소능수체격동제,여기타진통약물연합가이감소기타진통약물용량급기부작용. 목적 종술Dex재술후진통중적응용진전,위해약재진통중적응용제공삼고. 내용 종Dex적약리특성、진통궤제、각충급약도경、부작용등방면종술Dex재술후진통치료중적응용. 추향 Dex재진통방면유엄범적응용전경,단기안전성수요진일보적연구.
Background Postoperative pain is a nociceptive-based acute pain.Dexmedetomidine (Dex) is an α2 agonist.Combined Dex and other analgesics can reduce analgesic consumption and side effects.Objective This review describes the advances on the use of Dex in postoperative pain management in order to provide a practical guidance for postoperative analgesia.Content We review the use of Dex in postoperative pain management according to its pharmacological properties, analgesic mechanisms, various delivery methods and side effects.Trend The application of Dex in postoperative pain management is quite promising, but further studies adressing its security are still needed.
