CAJ | 학술논문

背景神经病理性疼痛(neuropathic pain,NP)是临床上常见的医学难题,因其形成机制复杂,目前尚缺乏有效的治疗手段.消退素(resolvn,Rv)Dl是一种新发现的内源性促炎症消退介质,对多种疼痛模型具有镇痛作用,然而其具体镇痛机制仍不明确.最近有研究发现,它可参与影响小胶质细胞激活状态,促进其M2型极化,而小胶质细胞的激活状态与NP等慢性神经炎性疾病密切相关. 目的分析RvD1是否可通过影响小胶质细胞的激活状态来产生镇痛作用. 内容简要介绍近来对于RvD1的镇痛作用及其与小胶质细胞活化关系的研究进展. 趋向完善RvD1的镇痛机制,探寻新的NP治疗方法.
배경 신경병이성동통(neuropathic pain,NP)시림상상상견적의학난제,인기형성궤제복잡,목전상결핍유효적치료수단.소퇴소(resolvn,Rv)Dl시일충신발현적내원성촉염증소퇴개질,대다충동통모형구유진통작용,연이기구체진통궤제잉불명학.최근유연구발현,타가삼여영향소효질세포격활상태,촉진기M2형겁화,이소효질세포적격활상태여NP등만성신경염성질병밀절상관. 목적 분석RvD1시부가통과영향소효질세포적격활상태래산생진통작용. 내용 간요개소근래대우RvD1적진통작용급기여소효질세포활화관계적연구진전. 추향 완선RvD1적진통궤제,탐심신적NP치료방법.
Background Neuropathic pain (NP) is a common clinical medical problem, because of its complex development mechanism, and there is still no effective treatment method currently.Resolvin (Rv) D1 is a newlv discovered endogenous proinflammatory resolution media.It has analgesic effects for a variety of pain models, but its specific analgesic mechanism remains unclear.Recent studies have found that it may be involved in influencing the microg]ia activation state, promoting the microglia towards M2 polarization.And the activation of microglia is closely related to the NP and other chronic neuroinflammatory diseases.Objective To study whether RvD1 produce analgesic effects by influencing the microglial activation state.Content This paper briefly introduces the research progress about the relations between its analgesic effect and microglia activation state recently.Trend Completing the analgesic mechanism of RvD1, and exploring new therapeutic methods of NP.