齐齐哈尔医学院学报
齊齊哈爾醫學院學報
제제합이의학원학보
Journal of Qiqihar University of Medicine
2015年
31期
4708-4710
,共3页
PAPPA%子痫前期%早产%死胎%胎盘早剥
PAPPA%子癇前期%早產%死胎%胎盤早剝
PAPPA%자간전기%조산%사태%태반조박
PAPPA%Preeclampsia%Fetal growth restriction%Pre-term birth%Stillbirth%Placental abruption
目的 探讨孕早期PAPPA水平在预测孕晚期不良妊娠结局子痫前期,胎儿生长受限,早产,死胎,胎盘早剥中的意义.方法 选取2014年1-12月在我院11~13 +6周行PAPPA检测并已在我院分娩的孕妇400例,将PAPPA<0.43MOM定为PAPPA降低,共收取PAPPA<0.43MOM的孕妇200例,PAPPA>0.43MOM的孕妇200例,比较两组不良妊娠结局的发生情况,并比较不同妊娠结局PAPPA水平.结果 PAPPA<0.43MOM组子痫前期,胎儿生长受限,死胎的发生率明显升高,早产,胎盘早剥的发生率无明显差异.PAPPA<0.43MOM组子痫前期,胎儿生长受限,死胎的发生风险为PAPPA>0.43MOM组的4.0,6.7,4.8倍(P<0.05);早产,胎盘早剥的发生风险为PAPPA》0.43MOM组的1.2,1.3倍(P>0.05).子痫前期,胎儿生长受限,死胎的孕早期PAPPA水平明显低于正常妊娠孕妇(P<0.05),早产,胎盘早剥孕妇的PAPPA水平与正常妊娠孕妇无明显差异(P>0.05).结论 孕早期PAPPA水平在预测孕晚期不良妊娠结局子痫前期,胎儿生长受限,死胎有重要意义.
目的 探討孕早期PAPPA水平在預測孕晚期不良妊娠結跼子癇前期,胎兒生長受限,早產,死胎,胎盤早剝中的意義.方法 選取2014年1-12月在我院11~13 +6週行PAPPA檢測併已在我院分娩的孕婦400例,將PAPPA<0.43MOM定為PAPPA降低,共收取PAPPA<0.43MOM的孕婦200例,PAPPA>0.43MOM的孕婦200例,比較兩組不良妊娠結跼的髮生情況,併比較不同妊娠結跼PAPPA水平.結果 PAPPA<0.43MOM組子癇前期,胎兒生長受限,死胎的髮生率明顯升高,早產,胎盤早剝的髮生率無明顯差異.PAPPA<0.43MOM組子癇前期,胎兒生長受限,死胎的髮生風險為PAPPA>0.43MOM組的4.0,6.7,4.8倍(P<0.05);早產,胎盤早剝的髮生風險為PAPPA》0.43MOM組的1.2,1.3倍(P>0.05).子癇前期,胎兒生長受限,死胎的孕早期PAPPA水平明顯低于正常妊娠孕婦(P<0.05),早產,胎盤早剝孕婦的PAPPA水平與正常妊娠孕婦無明顯差異(P>0.05).結論 孕早期PAPPA水平在預測孕晚期不良妊娠結跼子癇前期,胎兒生長受限,死胎有重要意義.
목적 탐토잉조기PAPPA수평재예측잉만기불량임신결국자간전기,태인생장수한,조산,사태,태반조박중적의의.방법 선취2014년1-12월재아원11~13 +6주행PAPPA검측병이재아원분면적잉부400례,장PAPPA<0.43MOM정위PAPPA강저,공수취PAPPA<0.43MOM적잉부200례,PAPPA>0.43MOM적잉부200례,비교량조불량임신결국적발생정황,병비교불동임신결국PAPPA수평.결과 PAPPA<0.43MOM조자간전기,태인생장수한,사태적발생솔명현승고,조산,태반조박적발생솔무명현차이.PAPPA<0.43MOM조자간전기,태인생장수한,사태적발생풍험위PAPPA>0.43MOM조적4.0,6.7,4.8배(P<0.05);조산,태반조박적발생풍험위PAPPA》0.43MOM조적1.2,1.3배(P>0.05).자간전기,태인생장수한,사태적잉조기PAPPA수평명현저우정상임신잉부(P<0.05),조산,태반조박잉부적PAPPA수평여정상임신잉부무명현차이(P>0.05).결론 잉조기PAPPA수평재예측잉만기불량임신결국자간전기,태인생장수한,사태유중요의의.
Objective To explore the predictive value of PAPPA level in the first trimester of pregnancy for the poor pregnancy outcome (preeclampsia,fetal growth restriction,stillbirth,pre-term birth,placental abruption) in the last trimester.Methods Patients who had tested PAPPA in the 11-13+6 weeks of pregnancy and registered for delivery in our hospital between January and December 2014 were taken into the trial.When PAPPA levelless than 0.43MOM,we called it PAPPA decreased.Contrasting pregnancy outcomes of pregnant women with PAPPA less than 0.43MOM(n=200) and PAPPA more than 0.43MOM(n =200).Contrasting PAPPA levels of different poor pregnancy outcomes.Results The occurrence rate of preeclampsia,stillbirth,fetal growth restriction was increased for those pregancy women with PAPPA<0.43MOM.But the occurrence rate of pre-term birth and placental abruption were not significantly increased.Woman with PAPPA<0.43MOM were at increased risk of preeclampsia,fetal growth restriction,stillbirth compared with PAPPA>0.43MOM(OR=4.0,6.7 and 4.8 respectively)(P<0.05).The OR of woman with PAPPA<0.43MOM were1.2 and 1.3 of pre-term birth,placental abruption compared with PAPPA>0.43MOM(P>0.05).PAPPA level of the pregnancy woman who suffered from preeclampsia,fetal growth restriction and stillbirth were obviously lower than the normal (P<0.05).PAPPA level of the pregnancy woman who suffered from pre-term birth,placental abruption were not obviously lower than the normal(P>0.05).Conclusions PAPPA level in the first trimester of pregnancy played an important role in predicting poor pregnancy outcome(preeclampsia,fetal growth restriction,stillbirth) in the last trimester.
