CAJ | 학술논문

目的：对3种漱口液在慢性阻塞性肺疾病（COPD）合并口腔真菌感染患者中的治疗效果进行比较，寻求其中最适合的漱口液。方法采用随机对照试验法，将 COPD 合并真菌感染的98例患者随机分为3组，分别使用碘伏法（0.5%碘伏）、制霉菌素溶液法（200万 U 制霉菌素粉末溶于2.5%NaHCO3溶液中）、制霉菌素甘油法（2.5%NaHCO3漱口液+200万 U 制霉菌素甘油局部涂抹）进行口腔护理，观察3组患者口腔真菌感染疗效以及患者和护士反馈情况。结果从白斑明显消失或者咽拭子涂片转阴性角度分析，碘伏法与制霉菌素甘油法差异无统计学意义，P>0.05，制霉菌素溶液法与制霉菌素甘油法比较差异有统计学意义，t=3.892，P<0.01；从患者口腔舒适度反馈角度来看，3组差异无统计学意义，P>0.05；从护士工作时间来看，尽管总时间无统计学意义，P>0.05，但碘伏法配制时间为制霉菌素甘油法的41.7%，制霉菌素溶液法为制霉菌素甘油法的54.4%。结论碘伏法在 COPD 合并口腔真菌感染患者中的疗效好，患者舒适度佳，最节约护士时间；制霉菌素溶液法起效时间不及制霉菌素甘油法。
목적：대3충수구액재만성조새성폐질병（COPD）합병구강진균감염환자중적치료효과진행비교，심구기중최괄합적수구액。방법채용수궤대조시험법，장 COPD 합병진균감염적98례환자수궤분위3조，분별사용전복법（0.5%전복）、제매균소용액법（200만 U 제매균소분말용우2.5%NaHCO3용액중）、제매균소감유법（2.5%NaHCO3수구액+200만 U 제매균소감유국부도말）진행구강호리，관찰3조환자구강진균감염료효이급환자화호사반궤정황。결과종백반명현소실혹자인식자도편전음성각도분석，전복법여제매균소감유법차이무통계학의의，P>0.05，제매균소용액법여제매균소감유법비교차이유통계학의의，t=3.892，P<0.01；종환자구강서괄도반궤각도래간，3조차이무통계학의의，P>0.05；종호사공작시간래간，진관총시간무통계학의의，P>0.05，단전복법배제시간위제매균소감유법적41.7%，제매균소용액법위제매균소감유법적54.4%。결론전복법재 COPD 합병구강진균감염환자중적료효호，환자서괄도가，최절약호사시간；제매균소용액법기효시간불급제매균소감유법。
Objective To compare the efficacy of three solutions used in the patients who suffered chronic obstructive pulmonary diseases (COPD ) when combined with oral fungal infection,and to find the most suitable one. Methods Using randomized controlled trial method, 98 patients who suffered COPD complicated with fungal infection were randomly divided into three groups. Method 1, using 0.5% povidone for the oral care. Method 2, making 200 million U of nystatin powder dissolved in 2.5% NaHCO3 for the oral care.Method 3, gave oral care with 2.5% NaHCO3 first, then put 200 million U of nystatin powder into 20 ml glycerol and covered the oral spots with them. Three groups were observed in the effect of oral fungal infection and the feedback from patients and nurses. Results In the analysis of the white spots sharply disappeared or pharyngeal swab smear turned negative, method 1 and method 3 had no statistical difference, P>0.05, but method 2 and method 3 had statistical significance, t=3.892, P <0.01; the three groups had no significant difference of feedback from the patients’ oral comfort, P >0.05. The time made solution of method 1 occupied 41.7% of method 3, and the time made solution of method 2 occupied 54.4%of method 3, while there was no statistical significance in total time of three groups (P>0.05). Conclusions The oral care with 0.5% povidone had good effect on the patients who suffered COPD complicated with oral fungal infection,with good comfort,and most nurses saving time. Nystatin powder dissolved in 2.5% NaHCO3 worked later than nystatin powder dissolved in glycerol.