CAJ | 학술논문

NKG2家族受体介导的自然杀伤（ NK ）细胞活化作为固有免疫应答核心组分，对乙型肝炎病毒（ HBV）感染的免疫控制以及病毒感染后疾病进展发挥重要调节作用。探讨NKG2受体介导的NK细胞活化机制对建立以NK细胞为靶向的抗HBV免疫治疗具有重要价值。该文就近年来关于NK细胞与其NKG2家族受体在慢性HBV感染免疫机制中的作用作了综述。
NKG2가족수체개도적자연살상（ NK ）세포활화작위고유면역응답핵심조분，대을형간염병독（ HBV）감염적면역공제이급병독감염후질병진전발휘중요조절작용。탐토NKG2수체개도적NK세포활화궤제대건립이NK세포위파향적항HBV면역치료구유중요개치。해문취근년래관우NK세포여기NKG2가족수체재만성HBV감염면역궤제중적작용작료종술。
The activation of NK cell , mediated by natural killer group 2 ( NKG2 ) family receptor , plays an important role in antiviral immune response and disease progression after hepatitis B virus (HBV) infection.To explore the NKG2 receptors-mediated NK cell activation and its mechanism may be of value for anti-HBV targeting immune treatment .This article reviews the recent research progress on the role of NK cells and its NKG2 family receptors in immunity of chronic HBV infection and its mechanisms .