吉林医学
吉林醫學
길림의학
Jilin Medical Journal
2015年
17期
3755-3757
,共3页
围绝经期综合征/ 更年期综合征%植物雌激素%大豆异黄酮%激素替代疗法(HRT)
圍絕經期綜閤徵/ 更年期綜閤徵%植物雌激素%大豆異黃酮%激素替代療法(HRT)
위절경기종합정/ 경년기종합정%식물자격소%대두이황동%격소체대요법(HRT)
Perimenopausal syndrome%Phytoestrogens%Soy isoflavones%Hormone replacement therapy(HRT)
目的：探讨植物雌激素治疗围绝经期综合征的临床疗效及其作用机制，比较植物雌激素与激素替代疗法治疗围绝经期综合征的临床疗效。方法：将180例围绝经期综合征患者按照就诊顺序随机分成 A、B 两组，分别运用大豆异黄酮和激素替代疗法进行治疗，应用 Kupper - man 症状评分标准判定临床疗效，并抽血检测治疗前后患者血清 E2、FSH、LH、P、AKP、TC、TG等各项指标，进行治疗前后对照观察。结果：经4个周期治疗后，患者的相关症状得到明显改善；与治疗前相比，Kupperman 评分显著下降，差异具有统计学意义（P ﹤0.01）；与治疗前相比，治疗后两组患者的 E2、P 均明显升高，而 FSH、LH、AKP、TC、TG 均明显降低，且差异具有统计学意义（P ﹤0.05）；两组间疗效差异无统计学意义（P ﹥0.05）。结论：植物雌激素能够有效改善围绝经期综合征的临床症状，调节围绝经期综合征患者体内激素水平，且疗效与激素替代疗法无显著性差异。植物雌激素还对绝经期及绝经后期妇女的心血管有保护作用，并可预防骨质疏松，防止骨量丢失。
目的：探討植物雌激素治療圍絕經期綜閤徵的臨床療效及其作用機製，比較植物雌激素與激素替代療法治療圍絕經期綜閤徵的臨床療效。方法：將180例圍絕經期綜閤徵患者按照就診順序隨機分成 A、B 兩組，分彆運用大豆異黃酮和激素替代療法進行治療，應用 Kupper - man 癥狀評分標準判定臨床療效，併抽血檢測治療前後患者血清 E2、FSH、LH、P、AKP、TC、TG等各項指標，進行治療前後對照觀察。結果：經4箇週期治療後，患者的相關癥狀得到明顯改善；與治療前相比，Kupperman 評分顯著下降，差異具有統計學意義（P ﹤0.01）；與治療前相比，治療後兩組患者的 E2、P 均明顯升高，而 FSH、LH、AKP、TC、TG 均明顯降低，且差異具有統計學意義（P ﹤0.05）；兩組間療效差異無統計學意義（P ﹥0.05）。結論：植物雌激素能夠有效改善圍絕經期綜閤徵的臨床癥狀，調節圍絕經期綜閤徵患者體內激素水平，且療效與激素替代療法無顯著性差異。植物雌激素還對絕經期及絕經後期婦女的心血管有保護作用，併可預防骨質疏鬆，防止骨量丟失。
목적：탐토식물자격소치료위절경기종합정적림상료효급기작용궤제，비교식물자격소여격소체대요법치료위절경기종합정적림상료효。방법：장180례위절경기종합정환자안조취진순서수궤분성 A、B 량조，분별운용대두이황동화격소체대요법진행치료，응용 Kupper - man 증상평분표준판정림상료효，병추혈검측치료전후환자혈청 E2、FSH、LH、P、AKP、TC、TG등각항지표，진행치료전후대조관찰。결과：경4개주기치료후，환자적상관증상득도명현개선；여치료전상비，Kupperman 평분현저하강，차이구유통계학의의（P ﹤0.01）；여치료전상비，치료후량조환자적 E2、P 균명현승고，이 FSH、LH、AKP、TC、TG 균명현강저，차차이구유통계학의의（P ﹤0.05）；량조간료효차이무통계학의의（P ﹥0.05）。결론：식물자격소능구유효개선위절경기종합정적림상증상，조절위절경기종합정환자체내격소수평，차료효여격소체대요법무현저성차이。식물자격소환대절경기급절경후기부녀적심혈관유보호작용，병가예방골질소송，방지골량주실。
Objective To investigate the phytoestrogen treatment of perimenopausal syndrome clinical efficacy and mechanism of ac-tion,compare phytoestrogens and hormone replacement therapy for perimenopausal syndrome clinical efficacy. Method 180 patients with perimenopausal syndrome were randomly divided into A and B groups according to treatment order,namely the use of soy isoflavones and hormone replacement therapy for treatment,application Kupper - man symptom score determines the clinical efficacy and treatment of blood testing the indicators before and after the patient serum E2、FSH、LH、P、AKP、TC、TG,were observed before and after treatment con-trol. Results After 4 cycles of therapy,the patient's symptoms improved significantly. Compared with before treatment,Kupperman score de-creased significantly(P ﹤ 0. 01). Compared with before treatment,two groups of patients after treatment,E2 and P were significantly in-creased,while FSH、LH、AKP、TC、TG were significantly reduced,and the difference was statistically significant(P ﹤ 0. 05). There was no significant difference efficacy between the two groups(P ﹥ 0. 05). Conclusion Phytoestrogens can effectively improve the clinical symp-toms of perimenopause syndrome,regulate hormone levels in perimenopausal syndrome,promote patient lipid metabolism,and no significant difference in the efficacy of hormone replacement therapy. Phytoestrogens also menopausal and postmenopausal women,cardiovascular pro-tective effect,and can prevent osteoporosis and prevent bone loss.
