中华胰腺病杂志
中華胰腺病雜誌
중화이선병잡지
Chinese Journal of Pancreatology
2015年
5期
302-305
,共4页
高脂血症性急性胰腺炎%胆源性急性胰腺炎%钙%甲状旁腺素
高脂血癥性急性胰腺炎%膽源性急性胰腺炎%鈣%甲狀徬腺素
고지혈증성급성이선염%담원성급성이선염%개%갑상방선소
Hyperlipidemic acute pancreatitis%Biliogenic acute pancreatitis%Calcium%Parathyroid hormone
目的 检测高脂血症性胰腺炎( HLAP)和胆源性急性胰腺炎( BAP )患者血钙( Ca )和全段甲状旁腺素( i-PTH)水平,分析它们间的相关性. 方法 收集2012年1月至2014年1月间首都医科大学附属北京朝阳医院收治的80例AP患者. 检测就诊时的血常规、肝肾功能、血脂、血Ca和i-PTH水平. 分析血Ca、i-PTH水平在HLAP组和BAP组间的差异及与AP 病情严重程度的相关性. 结果 80例AP患者中HLAP 43例,BAP 37例;轻度AP(MAP)55例,中度AP(MSAP)25例.HLAP组中男性34例,女性9例,平均年龄(37 ±11)岁;MAP 31例,MSAP 12例. BAP组中男性17例,女性20例,平均年龄(58 ±15)岁 ;MAP 24例,MSAP 13例. HLAP组的男性比例显著高于BAP组,而平均年龄显著低于BAP 组,差异均有统计学意义( P值均<0.01 );两组MAP与MSAP 患者比例的差异无统计学意义.HLAP组患者血Ca水平显著低于BAP组[(1.92 ±0.24)mmol/L比(2.14 ±1.99)mmol/L],差异有统计学意义(P<0.01),但两组患者血i-PTH水平的差异无统计学意义. HLAP组MAP、MSAP患者的血Ca水平分别为(1.98 ±0.20)、(1.76 ±0.27) mmol/L,BAP组分别为(2.23 ±0.15)、(1.98 ±0.19) mmol/L,两组MSAP患者的血Ca水平均显著低于MAP患者(P值均<0.01);HLAP组MAP、MSAP患者的血i-PTH水平分别为(43.41 ±18.40)、(56.07 ±33.61) ng/L,BAP 组分别为(39.22 ±17.19)、(52.73 ± 29.42)ng/L,两组MSAP患者i-PTH水平均显著高于MAP患者,但差异无统计学意义. HLAP组患者的血Ca水平与低密度脂蛋白胆固醇(LDL-C)、三酰甘油(TG)水平呈负相关(P值均<0.05);BAP组患者的血Ca水平与i-PTH水平呈负相关(P<0.05). 结论 HLAP和BAP患者的血Ca水平均随病情加重而降低. HLAP患者血Ca水平下降与LDL-C和TG水平升高相关,而BAP患者血Ca水平下降与i-PTH水平升高相关.
目的 檢測高脂血癥性胰腺炎( HLAP)和膽源性急性胰腺炎( BAP )患者血鈣( Ca )和全段甲狀徬腺素( i-PTH)水平,分析它們間的相關性. 方法 收集2012年1月至2014年1月間首都醫科大學附屬北京朝暘醫院收治的80例AP患者. 檢測就診時的血常規、肝腎功能、血脂、血Ca和i-PTH水平. 分析血Ca、i-PTH水平在HLAP組和BAP組間的差異及與AP 病情嚴重程度的相關性. 結果 80例AP患者中HLAP 43例,BAP 37例;輕度AP(MAP)55例,中度AP(MSAP)25例.HLAP組中男性34例,女性9例,平均年齡(37 ±11)歲;MAP 31例,MSAP 12例. BAP組中男性17例,女性20例,平均年齡(58 ±15)歲 ;MAP 24例,MSAP 13例. HLAP組的男性比例顯著高于BAP組,而平均年齡顯著低于BAP 組,差異均有統計學意義( P值均<0.01 );兩組MAP與MSAP 患者比例的差異無統計學意義.HLAP組患者血Ca水平顯著低于BAP組[(1.92 ±0.24)mmol/L比(2.14 ±1.99)mmol/L],差異有統計學意義(P<0.01),但兩組患者血i-PTH水平的差異無統計學意義. HLAP組MAP、MSAP患者的血Ca水平分彆為(1.98 ±0.20)、(1.76 ±0.27) mmol/L,BAP組分彆為(2.23 ±0.15)、(1.98 ±0.19) mmol/L,兩組MSAP患者的血Ca水平均顯著低于MAP患者(P值均<0.01);HLAP組MAP、MSAP患者的血i-PTH水平分彆為(43.41 ±18.40)、(56.07 ±33.61) ng/L,BAP 組分彆為(39.22 ±17.19)、(52.73 ± 29.42)ng/L,兩組MSAP患者i-PTH水平均顯著高于MAP患者,但差異無統計學意義. HLAP組患者的血Ca水平與低密度脂蛋白膽固醇(LDL-C)、三酰甘油(TG)水平呈負相關(P值均<0.05);BAP組患者的血Ca水平與i-PTH水平呈負相關(P<0.05). 結論 HLAP和BAP患者的血Ca水平均隨病情加重而降低. HLAP患者血Ca水平下降與LDL-C和TG水平升高相關,而BAP患者血Ca水平下降與i-PTH水平升高相關.
목적 검측고지혈증성이선염( HLAP)화담원성급성이선염( BAP )환자혈개( Ca )화전단갑상방선소( i-PTH)수평,분석타문간적상관성. 방법 수집2012년1월지2014년1월간수도의과대학부속북경조양의원수치적80례AP환자. 검측취진시적혈상규、간신공능、혈지、혈Ca화i-PTH수평. 분석혈Ca、i-PTH수평재HLAP조화BAP조간적차이급여AP 병정엄중정도적상관성. 결과 80례AP환자중HLAP 43례,BAP 37례;경도AP(MAP)55례,중도AP(MSAP)25례.HLAP조중남성34례,녀성9례,평균년령(37 ±11)세;MAP 31례,MSAP 12례. BAP조중남성17례,녀성20례,평균년령(58 ±15)세 ;MAP 24례,MSAP 13례. HLAP조적남성비례현저고우BAP조,이평균년령현저저우BAP 조,차이균유통계학의의( P치균<0.01 );량조MAP여MSAP 환자비례적차이무통계학의의.HLAP조환자혈Ca수평현저저우BAP조[(1.92 ±0.24)mmol/L비(2.14 ±1.99)mmol/L],차이유통계학의의(P<0.01),단량조환자혈i-PTH수평적차이무통계학의의. HLAP조MAP、MSAP환자적혈Ca수평분별위(1.98 ±0.20)、(1.76 ±0.27) mmol/L,BAP조분별위(2.23 ±0.15)、(1.98 ±0.19) mmol/L,량조MSAP환자적혈Ca수평균현저저우MAP환자(P치균<0.01);HLAP조MAP、MSAP환자적혈i-PTH수평분별위(43.41 ±18.40)、(56.07 ±33.61) ng/L,BAP 조분별위(39.22 ±17.19)、(52.73 ± 29.42)ng/L,량조MSAP환자i-PTH수평균현저고우MAP환자,단차이무통계학의의. HLAP조환자적혈Ca수평여저밀도지단백담고순(LDL-C)、삼선감유(TG)수평정부상관(P치균<0.05);BAP조환자적혈Ca수평여i-PTH수평정부상관(P<0.05). 결론 HLAP화BAP환자적혈Ca수평균수병정가중이강저. HLAP환자혈Ca수평하강여LDL-C화TG수평승고상관,이BAP환자혈Ca수평하강여i-PTH수평승고상관.
Objective To investigate the correlation and differences of serum calcium ( Ca) and intact parathyroid hormone ( i-PTH) in patients with hyperlipidemic or biliogenic acute pancreatitis ( AP) .Methods From Jan 2012 to Jan 2014 , total 80 AP patients admitted to Bejing Chaoyang Hospital were enrolled . According to the etiology , AP patients were divided into 2 groups, hyperlipidemic acute pancreatitis ( HLAP) group and biliogenic acute pancreatitis (BAP) group.Blood routine, function of liver and kidney , blood lipids, Ca, and i-PTH were measured .Differences between Ca and i-PTH in HLAP group and BAP group were analyzed, and found the correlation with disease severity of AP .Results 80 AP patients included 43 HLAP and 37 BAP patients, 55 mild acute pancreatitis(MAP) and 25 moderately severe acute pancreatitis (MSAP) patients.HLAP group had 34 male and 9 female patients, average age was 37 years, 31 MAP and 12 MSAP patients.BAP group had 17 male and 20 female patients, average age was 58 years, 24 MAP and 13 MSAP patients.proportion of males was significantly higher in HLAP group than BAP group .on the contrary, average age was significantly lower (P<0.01 and <0.01, respectively).No significantly difference was found in MAP/MSAP ration.Level of serum Ca in HLAP group was significantly decreased than BAP group (1.92 ± 0.24 mmol/L vs 2.14 ±1.99 mmol/L, P<0.05).No significantly difference was found in i-PTH between two groups.Level of serum Ca in MAP and MSAP subgroup in HLAP group were 1.98 ±0.20 mmol/L and 1.76 ± 0.27 mmol/L.Accordingly, Level of serum Ca were 2.23 ±0.15 mmol/L and 1.98 ±0.19 mmol/L in BAP group. i-PTH in MAP and MSAP subgroup in HLAP group were 43.41 ±18.40 ng/L and 56.07 ±33.61 ng/L.Accordingly, i-PTH was 39.22 ±17.19 mmol/L and 52.73 ±29.42 mmol/L in BAP group.Compared to MAP, Ca in MSAP group was significantly decreased in HLAP and BAP group ( P<0.01 and <00.5, respectively).In HLAP group, Ca was a negative correlation with low density lipoprotein cholesterol (LDLC-) and triglycerides(TG) (P<0.05 and <0.01, respectively).In BAP group, Ca was a negative correlation with i-PTH(P<0.05).Conclusions Serum Ca is decreased with severity of HLAP and BAP .Decreased Ca has correlation with increased LDL-C, TG in HLAP and increased i-PTH in BAP.
