CAJ | 학술논문

目前眼部给药途径有眼表、结膜下、前房、巩膜、玻璃体腔给药和全身给药,人工晶状体(intraocular lens,IOL)是一个新型的潜在眼内载药系统.其优点为,药物直接曝露于前房,可以提高药物有效浓度;植入药物无需额外操作;IOL固定在囊袋或者睫状沟内也保证了药物位置的稳定性.目前将药物加载到IOL上的方法主要有浸泡吸附法、眼内植入剂法、等离子体接枝法、离子束注入法、化学交联接枝法、静电层层组装涂层法、高压静电喷涂法、超临界流体法等.IOL给药系统主要用于治疗眼内炎性反应和后发性白内障等白内障术后并发症.
목전안부급약도경유안표、결막하、전방、공막、파리체강급약화전신급약,인공정상체(intraocular lens,IOL)시일개신형적잠재안내재약계통.기우점위,약물직접폭로우전방,가이제고약물유효농도;식입약물무수액외조작;IOL고정재낭대혹자첩상구내야보증료약물위치적은정성.목전장약물가재도IOL상적방법주요유침포흡부법、안내식입제법、등리자체접지법、리자속주입법、화학교련접지법、정전층층조장도층법、고압정전분도법、초림계류체법등.IOL급약계통주요용우치료안내염성반응화후발성백내장등백내장술후병발증.
Delivering drugs to the ocular system has many approaches including topical, subconjunctival, intracameral, scleral, intravitreal, oral or intravenous administration.Intraocular lens (IOL) as an innovative drug reservoir has many advantages.Drug loading to IOL could work directly to the anterior chamber, providing higher intraocular drug concentration.It combines cataract surgery and postoperative treatments in a single procedure.Moreover IOL remains immobilized within the capsular bag or ciliary sulcus as a fixed drug releaser meanwhile.Nowadays several approaches undergone study to endow IOL with the ability of carrying different drugs are listed as followings : soaking, attaching a polymeric drug reservoir, plasma grafting, chemical grafting, layer-by-layer self-assembly deposition, coating, supercritical fluids impregnation and so on.IOL drug delivery systems are mainly designed to treat against the complications of cataract surgery such as endophthalmitis, inflammation reaction and posterior capsular opacification.