CAJ | 학술논문

目的：探讨β3肾上腺素能受体（β3-AR）基因 Trp64Arg 变异与儿童肥胖易感性的关联。方法通过计算机检索 PubMed、Web of Science、Springer Link、超星 Medlink、中国生物医学文献服务系统、万方、维普和 CNKI 数据库，检索1995年1月至2014年2月公开发表的关于β3-AR 基因多态性与儿童肥胖关联的病例对照研究。根据统一的纳入排除标准，筛选文献，应用 RevMan 5.1软件对各纳入文献进行异质性检验及效应值合并，同时进行敏感性分析和偏倚估计。结果共检索到相关文献162篇，最终纳入符合条件的文献9篇，其中肥胖儿童1494例，正常体质量儿童1623人。等位基因 T 与 C 比较，中国病例组与对照组间的差异有统计学意义（P 约0.05），同样 TC + CC 与 TT 比较及 TC 与 TT + CC 比较得到相似的结果；日本的研究结果与中国相似，但匈牙利病例组与对照组间的差异无统计学意义（P ﹥0.05）。各研究的敏感性分析比较稳定，且漏斗图形基本对称。敏感性分析和发表偏倚分析证实上述 Meta 分析结果是稳定和可靠的。结论 TC + CC/ TT、TC/TT + CC 基因型和 T/ C 等位基因均与中国、日本儿童肥胖的发生有关，但与匈牙利儿童肥胖的发生无明显相关。β3-AR 基因 Trp64Arg 变异与儿童肥胖遗传易感性存在地区差异性。
목적：탐토β3신상선소능수체（β3-AR）기인 Trp64Arg 변이여인동비반역감성적관련。방법통과계산궤검색 PubMed、Web of Science、Springer Link、초성 Medlink、중국생물의학문헌복무계통、만방、유보화 CNKI 수거고，검색1995년1월지2014년2월공개발표적관우β3-AR 기인다태성여인동비반관련적병례대조연구。근거통일적납입배제표준，사선문헌，응용 RevMan 5.1연건대각납입문헌진행이질성검험급효응치합병，동시진행민감성분석화편의고계。결과공검색도상관문헌162편，최종납입부합조건적문헌9편，기중비반인동1494례，정상체질량인동1623인。등위기인 T 여 C 비교，중국병례조여대조조간적차이유통계학의의（P 약0.05），동양 TC + CC 여 TT 비교급 TC 여 TT + CC 비교득도상사적결과；일본적연구결과여중국상사，단흉아리병례조여대조조간적차이무통계학의의（P ﹥0.05）。각연구적민감성분석비교은정，차루두도형기본대칭。민감성분석화발표편의분석증실상술 Meta 분석결과시은정화가고적。결론 TC + CC/ TT、TC/TT + CC 기인형화 T/ C 등위기인균여중국、일본인동비반적발생유관，단여흉아리인동비반적발생무명현상관。β3-AR 기인 Trp64Arg 변이여인동비반유전역감성존재지구차이성。
Objective To investigate the relationship between β3 - adrenergic receptor(β3 - AR)gene poly-morphism and the susceptibility of occurrence in children obesity. Methods The database of PubMed,Web of Science,Springer Link,Medlink,SinoMed,Wanfang,VIP and CNKI were systematically browsed online. The study re-ports regarding β3 - AR associated with children obesity from January 1995 to February 2014 were included in the re-search. The data were extracted,evaluated and heterogeneity tested by using software RevMan 5. 1. Results A total of 162 related literature were retrieved,and 9 of them were eligible with 1 494 obese children and 1 623 normal children were included. Allele T compared with C,the differences between the study group and the control group were statistical-ly significant(P < 0. 05),the findings from the same TC + CC compared to TT and TC compared with TT + CC were similar. Japanese research findings were similar to those of China,but the differences between the study group and the control group had no statistical significance(P ﹥ 0. 05)in Hungary. The sensitivity analysis in each study was stable and the funnel graphics were basically symmetric. The results of sensitivity analysis and publication bias diagnostics demonstrated the reliability and stability of the Meta analysis. Conclusions TC + CC/ TT,TC/ TT + CC genotype and allele T/ C are related to the occurrence of childhood obesity in China,Japan,but there is no significant correlation with childhood obesity in Hungary. There are regional difference between β3 - AR gene polymorphism and genetic susceptibility to children obesity.