CAJ | 학술논문

背景：国内外关于如何成功构建组织工程牙支架材料内部空间构型的文献报道较少。 　　目的：建立适用于组织工程牙需求的支架材料CAD空间构型及支架结构实体微观模型STL格式文件。 　　方法：采用MICRO CT对离体大鼠第二磨牙进行连续扫描，将MICRO CT获得的DICOM格式文件导入MIMICS软件，将生成的三维模型导入 GEOMAGIC12软件，提取外层轮廓，利用偏移功能模拟得到大鼠磨牙外层轮廓数据。利用CATIA V5R17软件构建支架材料空间内部多孔微观模型单体，在空间合适坐标上阵列得到组织工程牙内部支架整体模型，通过变更单体构型还可快速建立多种整体支架构型。装配大鼠磨牙外层轮廓数据与内部空间支架得到三维打印组织工程牙CAD 模型STL文件。 　　结果与结论：成功建立了牙体组织支架微观结构CAD模型，该CAD STL模型可直接用于三维打印系统快速成型组织工程牙支架。说明基于结合计算机逆向与正向工程建模技术，可快速建立多种符合组织工程牙要求的支架材料空间构型。
배경：국내외관우여하성공구건조직공정아지가재료내부공간구형적문헌보도교소。 　　목적：건립괄용우조직공정아수구적지가재료CAD공간구형급지가결구실체미관모형STL격식문건。 　　방법：채용MICRO CT대리체대서제이마아진행련속소묘，장MICRO CT획득적DICOM격식문건도입MIMICS연건，장생성적삼유모형도입 GEOMAGIC12연건，제취외층륜곽，이용편이공능모의득도대서마아외층륜곽수거。이용CATIA V5R17연건구건지가재료공간내부다공미관모형단체，재공간합괄좌표상진렬득도조직공정아내부지가정체모형，통과변경단체구형환가쾌속건립다충정체지가구형。장배대서마아외층륜곽수거여내부공간지가득도삼유타인조직공정아CAD 모형STL문건。 　　결과여결론：성공건립료아체조직지가미관결구CAD모형，해CAD STL모형가직접용우삼유타인계통쾌속성형조직공정아지가。설명기우결합계산궤역향여정향공정건모기술，가쾌속건립다충부합조직공정아요구적지가재료공간구형。
BACKGROUND:There are less reports on how to successfuly build the internal spatial configuration of tissue-engineered tooth scaffolds. OBJECTIVE:To find a way to establish a series of three-dimensional digital modes for tissue-engineered tooth scaffold, such as CAD spatial configuration and Standard Template Library (STL) files. METHODS:In order to get three-dimensional printing format of STL files, MICRO CT data of DICOM format were input into MIMICS and GEOMAGIC softwares, creating the outline of STL files. Then CATIA V5R17 software was used to create the three-dimensional digital mode of tissue-engineered tooth. Then, the overal model of the internal scaffold was obtained by arraying at the proper coordinates. Various overal scaffold configurations could be built rapidly by varying monomer configuration. The STL files of CAD model of three-dimensional printing tissue-engineered tooth were obtained by assembling the tooth outline mode and the internal scaffold. RESULTS AND CONCLUSION: The CAD model was constructed successfuly, and this model could be directly used for three-dimensional printing rapid prototyping system to produce tissue-engineered tooth scaffolds. These findings indicate that the three-dimensional digital mode based on reverse engineering and positive engineering can be established, which can be used to quickly build a variety of internal spatial configurations of scaffold materials required for tissue-engineered teeth.