CAJ | 학술논문

Patatin样磷酯酶结构域蛋白3(PNPLA3)基因 I148M多态性在肝脏中表达,并参与主要的脂质代谢过程,它主要通过影响组织代谢和肝脏酶学,进而促进肝脏脂肪变、炎症和纤维化. PNPLA3基因I148M多态性对肝非实质细胞也有影响,可以直接促进肝纤维化. 此文对此研究进展作一综述.
Patatin양린지매결구역단백3(PNPLA3)기인 I148M다태성재간장중표체,병삼여주요적지질대사과정,타주요통과영향조직대사화간장매학,진이촉진간장지방변、염증화섬유화. PNPLA3기인I148M다태성대간비실질세포야유영향,가이직접촉진간섬유화. 차문대차연구진전작일종술.
Recent studies indicate that patatin-like phospholipase domain-containing protein 3 (PNPLA3) gene I148M polymorphism expresses in the liver and takes a key role in lipid metabolism. It affects tissue metabolism and liver enzymes, thus influences liver steatosis, inflammation and fibrosis. In addition, it affects the functions of liver non-parenchymal cell and promotes liver fibrosis directly. The research progress on these aspects are reviewed in this paper.