CAJ | 학술논문

目的：检测支气管哮喘（简称哮喘）儿童中呼出气一氧化氮的水平以及与肺功能的相关性，并探讨一氧化氮检测在儿童哮喘中的诊疗价值。方法选取贵阳市妇幼保健院72例哮喘儿童，根据儿童哮喘严重程度分为非重度哮喘组与重度哮喘组，各36例。测定一氧化氮水平，同时测定肺功能，采用 SPSS 13.0软件进行统计学分析。结果重度哮喘组儿童一氧化氮水平为（47±26）ppb，较非重度哮喘组儿童一氧化氮水平[（29±15）ppb]显著增高（t ＝3.543，P ﹤0.01）；1秒率、最大呼气中段流量（MMEF）、呼气峰流速（PEF）占预计百分比非重度组明显高于重度组[（99.74±9.81）％比（87.17±13.30）％，（87.12±35.61）％比（68.90±30.88）％，（99.97±10.83）％比（94.31±17.69）％]（P ﹤0.01、0.05、0.05）；非重度哮喘组儿童一氧化氮和肺功能各项参数，包括[第1秒用力呼气容积（FEV1）、1秒率、MMEF、PEF 均无相关性（r ＝0.073、0.087、0.242、0.326，P 均﹥0.05）；重度哮喘组一氧化氮水平与 FEV1、1秒率、MMEF、PEF 均呈负相关（r ＝-0.354、-0.573、
목적：검측지기관효천（간칭효천）인동중호출기일양화담적수평이급여폐공능적상관성，병탐토일양화담검측재인동효천중적진료개치。방법선취귀양시부유보건원72례효천인동，근거인동효천엄중정도분위비중도효천조여중도효천조，각36례。측정일양화담수평，동시측정폐공능，채용 SPSS 13.0연건진행통계학분석。결과중도효천조인동일양화담수평위（47±26）ppb，교비중도효천조인동일양화담수평[（29±15）ppb]현저증고（t ＝3.543，P ﹤0.01）；1초솔、최대호기중단류량（MMEF）、호기봉류속（PEF）점예계백분비비중도조명현고우중도조[（99.74±9.81）％비（87.17±13.30）％，（87.12±35.61）％비（68.90±30.88）％，（99.97±10.83）％비（94.31±17.69）％]（P ﹤0.01、0.05、0.05）；비중도효천조인동일양화담화폐공능각항삼수，포괄[제1초용력호기용적（FEV1）、1초솔、MMEF、PEF 균무상관성（r ＝0.073、0.087、0.242、0.326，P 균﹥0.05）；중도효천조일양화담수평여 FEV1、1초솔、MMEF、PEF 균정부상관（r ＝-0.354、-0.573、
Objective To examine the levels of fractional exhaled nitric oxide in bronchial asthma and the cor-relation between fractional exhaled nitric oxide and pulmonary function tests as well as the value of pulmonary function tests in curing the children with bronchial asthma. Methods Seventy - two asthmatic children came from Guiyang Ma-ternal and Child Health Hospital were studied. They were divided into 2 groups:mild - to - moderate asthma group(36 cases)and serious asthma group(36 cases). Fractional exhaled nitric oxide level and the lung function were measured and the correlation analysis was analyzed by SPSS 13. 0 software. Results The fractional exhaled nitric oxide concen-tration of the serious asthma group was significantly higher than that of the mild - to - moderate asthma group[(47 ± 26)ppb vs(29 ± 15)ppb,t = 3. 543,P ﹤ 0. 01],1 - second rate,maximum mid - expiratory flow(MMEF),and peak expiratory flow(PEF)in mild - to - moderate asthma group were significantly higher than those in serious asthma group[(99. 74 ± 9. 81)% vs(87. 17 ± 13. 30)% ,(87. 12 ± 35. 61)% vs(68. 90 ± 30. 88)% ,(99. 97 ± 10. 83)% vs (94. 31 ± 17. 69)% ](P ﹤ 0. 01,0. 05,0. 05). No correlations were found between fractional exhaled nitric oxide level and the lung function parameters,including forced expiratory volume in 1s(FEV1),1 - second rate,MMEF and PEF in the mild - to - moderate asthma group(r = 0. 073,0. 087,0. 242,0. 326,all P ﹥ 0. 05). However the level of fractional exhaled nitric oxide was negatively correlated with the lung function parameters,including FEV1,FEV1 / FVC,MMEF and PEF in serious asthma group(r = - 0. 354,- 0. 573,- 0. 478,- 0. 471,P ﹤ 0. 05,0. 001,0. 005,0. 005),respec-tively. Conclusions Monitoring of fractional exhaled nitric oxide and the lung function parameters can effectively indi-cate the state of illness of asthmatic child,which plays a key role in the treatment.