CAJ | 학술논문

背景：国内外已经研制出多种体外细胞张应力加载装置，主要拉伸方法有矩形基底拉伸法、圆形基底变形法和4点弯曲梁加载法3种，其中圆形基底变形法虽能够很好的反映体内如肺泡的扩张、血管的脉动等真实情况，但该种加载过程中膜的应变是辐射对称的；4点弯曲梁加载法能够提供的应变范围很小，加载时间有限，应变调节比较困难。 　　目的：采用矩形基底拉伸法研制血管张应力体外加载装置。 　　方法：采用机电一体化设计研制血管张应力体外加载装置，由电源模块、控制模块、传动模块和数据采集模块4个部分组成，以硅胶片为基底材料，通过对电机旋转角度和转动速度的高精度控制，实现对硅胶膜片上的拉伸控制。 　　结果与结论：通过测试和试验，该装置可以满足试验所需的参数范围，能够在体外模拟出人体张应力环境，初步认为该张应力加载装置的研制是成功的，实现了：①装置有两种工作模式：应力模式和应变模式，解决了基底加载装置的硅胶片材还没有实现标准化的问题。②能实现张应力在0-5×105 Pa范围内的调节。③能实现张应变在0-40%范围内的调节。④能实现0-80次/min的拉伸频率的变化，并能控制拉伸时间。
배경：국내외이경연제출다충체외세포장응력가재장치，주요랍신방법유구형기저랍신법、원형기저변형법화4점만곡량가재법3충，기중원형기저변형법수능구흔호적반영체내여폐포적확장、혈관적맥동등진실정황，단해충가재과정중막적응변시복사대칭적；4점만곡량가재법능구제공적응변범위흔소，가재시간유한，응변조절비교곤난。 　　목적：채용구형기저랍신법연제혈관장응력체외가재장치。 　　방법：채용궤전일체화설계연제혈관장응력체외가재장치，유전원모괴、공제모괴、전동모괴화수거채집모괴4개부분조성，이규효편위기저재료，통과대전궤선전각도화전동속도적고정도공제，실현대규효막편상적랍신공제。 　　결과여결론：통과측시화시험，해장치가이만족시험소수적삼수범위，능구재체외모의출인체장응력배경，초보인위해장응력가재장치적연제시성공적，실현료：①장치유량충공작모식：응력모식화응변모식，해결료기저가재장치적규효편재환몰유실현표준화적문제。②능실현장응력재0-5×105 Pa범위내적조절。③능실현장응변재0-40%범위내적조절。④능실현0-80차/min적랍신빈솔적변화，병능공제랍신시간。
BACKGROUND:After years of development, various in vitro loading devices for vascular tension stress have been created both at home and abroad, mainly including rectangular base stretching method, circular base deformation method and four-point bending beam load method. Although the circular base deformation method can wel reflect the real situations in vivo such as the expansion of the alveoli and vascular pulsation, the strain on the membrane is actinomorphic. The four-point bending beam load method can just bring limited strain range and load time, along with a difficult strain regulation. OBJECTIVE: To develop anin vitro loading device for vascular tension stress using the rectangular base stretching method. METHODS:Thisin vitro loading device for vascular tension stress developed according to mechatronics design consisted of power supply module, control module, drive module and data acquisition module. The device could achieve the tensile control on silicon diaphragm by high-precision control of the motor rotation angle and rotational speed. RESULTS AND CONCLUSION: Through tests and experiments, the device could meet the required range of parameters and simulatein vitro human tensile stress environment, which is preliminarily considered to develop successfuly, achieving that: (1) two work patterns: stress mode and strain mode so as to solve the standardization of silicone substrate as loading device; (2) tensile stress can be adjusted in a range of 0-5×105 Pa; (3) tensile strain can be adjusted in 0-40% range; (4) stretching frequency can be in the regulation of 0-80 times/min and the stretching time can be controled.